topic Re: proc mixed between and within factors in Statistical Procedures https://communities.sas.com/t5/Statistical-Procedures/proc-mixed-between-and-within-factors/m-p/699601#M33738 <P>You can, but be sure to include the random statements as in the current model, especially the group=group*compound option to deal with the heterogeneity of variance issue.&nbsp; I don't know why you would drop it, though. It is a known design factor, the F tests, lsmeans and lsmean difference p values for tests of group, compound and group by compound are no different, and you get some insight into which whole plot factors have the largest effect on the repeat to repeat variability.</P> <P>&nbsp;</P> <P>SteveDenham</P> Tue, 17 Nov 2020 20:14:10 GMT SteveDenham 2020-11-17T20:14:10Z proc mixed between and within factors https://communities.sas.com/t5/Statistical-Procedures/proc-mixed-between-and-within-factors/m-p/698390#M33685 <P>Dear Community,</P><P>I have troubles in using PROC MIXED OR PROC GLIMMIXED. My experiment consist of 12 control and 12 diseased animals (group factor). Cultured cells from each animal are treated with 4 compounds (repeated measures factor) and the measure of a signal is replicated 5 times (repeated measures factor).</P><P>I would like to test for group effect and compound effect and possibly their interaction taking into account the nested repeated measures nature of the experiment.</P><P>&nbsp;</P><P>I also have a similar experiment where the numeber of animals and the number is variable as regard the group, the compound end the replicates.</P><P>&nbsp;</P><P>Thanks for your help</P> Thu, 12 Nov 2020 14:17:22 GMT https://communities.sas.com/t5/Statistical-Procedures/proc-mixed-between-and-within-factors/m-p/698390#M33685 ACF1 2020-11-12T14:17:22Z Re: proc mixed between and within factors https://communities.sas.com/t5/Statistical-Procedures/proc-mixed-between-and-within-factors/m-p/698647#M33699 <P>If your response variable is continuous, you can fit a Kronecker product in the REPEATED statement of PROC MIXED.&nbsp; See the short example&nbsp;<A href="https://documentation.sas.com/?docsetId=statug&amp;docsetTarget=statug_mixed_syntax14.htm&amp;docsetVersion=15.2&amp;locale=en#statug.mixed.repeatedstmt_type" target="_self">here</A>&nbsp;.</P> <P>&nbsp;</P> <P>For GLIMMIX, multivariate repeated measures are not so simple.&nbsp; See my reply in this thread&nbsp;<A href="https://communities.sas.com/t5/Statistical-Procedures/repeated-measures-in-glimmix/td-p/128310" target="_self">https://communities.sas.com/t5/Statistical-Procedures/repeated-measures-in-glimmix/td-p/128310</A>&nbsp; or here&nbsp;<A href="https://communities.sas.com/t5/Statistical-Procedures/Doubly-repeated-measures-with-GLIMMIX/td-p/116837" target="_self">https://communities.sas.com/t5/Statistical-Procedures/Doubly-repeated-measures-with-GLIMMIX/td-p/116837,</A></P> <P>&nbsp;</P> <P>The latter is an incomplete version of this fantastic blog by the Ontario Agriculture College's statistical support group:</P> <P><A href="https://oacstats.blog/2018/04/23/ridgetown-workshop-repeated-measures-adding-year-location/" target="_self">https://oacstats.blog/2018/04/23/ridgetown-workshop-repeated-measures-adding-year-location/</A>&nbsp;</P> <P>&nbsp;</P> <P>This gives code for a doubly repeated measures analysis in GLIMMIX.</P> <P>&nbsp;</P> <P>SteveDenham&nbsp;</P> Fri, 13 Nov 2020 13:40:13 GMT https://communities.sas.com/t5/Statistical-Procedures/proc-mixed-between-and-within-factors/m-p/698647#M33699 SteveDenham 2020-11-13T13:40:13Z Re: proc mixed between and within factors https://communities.sas.com/t5/Statistical-Procedures/proc-mixed-between-and-within-factors/m-p/698673#M33704 Hi Steve,<BR />thanks for your suggestion. Unfortunately it seems not working.<BR />I tried this model:<BR /><BR />PROC GLIMMIX DATA=mydata PLOTS=ALL ;<BR />CLASS animal group compound repeat ;<BR />MODEL signal = groupt|compound ;<BR />RANDOM repeat / SUBJECT=animal ;<BR />RANDOM compound / SUBJECT=animal*repeat TYPE=UN ;<BR />LSMEANS group|compound / CL ;<BR />RUN;<BR /><BR />but it doesn't work, this is the log:<BR /><BR />WARNING: MIVQUE0 estimate of profiled variance is linearly related to other<BR />covariance parameters.<BR />NOTE: Convergence criterion (FCONV=2.220446E-16) satisfied.<BR />NOTE: At least one element of the gradient is greater than 1e-3.<BR />NOTE: A linear combination of covariance parameters is confounded with the<BR />residual variance.<BR /><BR /><BR /> Fri, 13 Nov 2020 14:27:39 GMT https://communities.sas.com/t5/Statistical-Procedures/proc-mixed-between-and-within-factors/m-p/698673#M33704 ACF1 2020-11-13T14:27:39Z Re: proc mixed between and within factors https://communities.sas.com/t5/Statistical-Procedures/proc-mixed-between-and-within-factors/m-p/699135#M33722 <P>Well, in some sense, things worked (convergence is good), but the thing to notice here is that you aren't fitting 'repeat' in the model.&nbsp; Give this a try:</P> <P>&nbsp;</P> <PRE><CODE class=" language-sas">PROC GLIMMIX DATA=mydata PLOTS=ALL ; CLASS animal group compound repeat ; MODEL signal = group|compound|repeat ; RANDOM intercept / SUBJECT=animal group=compound ; RANDOM repeat / SUBJECT=animal residual TYPE=cs ; LSMEANS group|compound / CL ; RUN;</CODE></PRE> <P>I still feel that this is missing something from the OAC reference, as you don't have a factor equivalent to their 'rep' variable, so I am not sure if the first RANDOM statement will do what is needed.. I might be missing what the experimental unit is in this case.&nbsp; I think 'animal' is a block equivalent to 'rep' in the OAC, in which case you should have some variable ID'ing what was sampled from the animal.&nbsp; The more I think about this, that would be 'compound' so you have confounding of compound with the experimental unit.&nbsp; I definitely feel like I am missing a key element in the design.</P> <P>&nbsp;</P> <P>SteveDenham</P> <P>&nbsp;</P> Mon, 16 Nov 2020 14:00:40 GMT https://communities.sas.com/t5/Statistical-Procedures/proc-mixed-between-and-within-factors/m-p/699135#M33722 SteveDenham 2020-11-16T14:00:40Z Re: proc mixed between and within factors https://communities.sas.com/t5/Statistical-Procedures/proc-mixed-between-and-within-factors/m-p/699203#M33724 <P>Here my design and my data: 12 diseased (D) animals and 12 controls (ctrl) are assigned to receive all of 4 compounds (first repeated factor) and there is a signal measured 5 times for each coumpound on each animal (second repeated factor, but I'm not interested in this effect).</P><P>&nbsp;</P><TABLE><TBODY><TR><TD>Group</TD><TD>Compound</TD><TD>Animal</TD><TD>Repeat</TD><TD>Signal</TD></TR><TR><TD>D</TD><TD>1</TD><TD>D1</TD><TD>1</TD><TD>299092</TD></TR><TR><TD>D</TD><TD>1</TD><TD>D1</TD><TD>2</TD><TD>280073</TD></TR><TR><TD>D</TD><TD>1</TD><TD>D1</TD><TD>3</TD><TD>239451</TD></TR><TR><TD>D</TD><TD>1</TD><TD>D1</TD><TD>4</TD><TD>256468</TD></TR><TR><TD>D</TD><TD>1</TD><TD>D1</TD><TD>5</TD><TD>285194</TD></TR><TR><TD>D</TD><TD>1+2</TD><TD>D1</TD><TD>1</TD><TD>348124</TD></TR><TR><TD>D</TD><TD>1+2</TD><TD>D1</TD><TD>2</TD><TD>336914</TD></TR><TR><TD>D</TD><TD>1+2</TD><TD>D1</TD><TD>3</TD><TD>369524</TD></TR><TR><TD>D</TD><TD>1+2</TD><TD>D1</TD><TD>4</TD><TD>307687</TD></TR><TR><TD>D</TD><TD>1+2</TD><TD>D1</TD><TD>5</TD><TD>316932</TD></TR><TR><TD>D</TD><TD>1+2+3</TD><TD>D1</TD><TD>1</TD><TD>358802</TD></TR><TR><TD>D</TD><TD>1+2+3</TD><TD>D1</TD><TD>2</TD><TD>389635</TD></TR><TR><TD>D</TD><TD>1+2+3</TD><TD>D1</TD><TD>3</TD><TD>397721</TD></TR><TR><TD>D</TD><TD>1+2+3</TD><TD>D1</TD><TD>4</TD><TD>418724</TD></TR><TR><TD>D</TD><TD>1+2+3</TD><TD>D1</TD><TD>5</TD><TD>420941</TD></TR><TR><TD>D</TD><TD>1+3</TD><TD>D1</TD><TD>1</TD><TD>415534</TD></TR><TR><TD>D</TD><TD>1+3</TD><TD>D1</TD><TD>2</TD><TD>371207</TD></TR><TR><TD>D</TD><TD>1+3</TD><TD>D1</TD><TD>3</TD><TD>384587</TD></TR><TR><TD>D</TD><TD>1+3</TD><TD>D1</TD><TD>4</TD><TD>428517</TD></TR><TR><TD>D</TD><TD>1+3</TD><TD>D1</TD><TD>5</TD><TD>415308</TD></TR><TR><TD>D</TD><TD>1</TD><TD>D2</TD><TD>1</TD><TD>451305</TD></TR><TR><TD>D</TD><TD>1</TD><TD>D2</TD><TD>2</TD><TD>442801</TD></TR><TR><TD>D</TD><TD>1</TD><TD>D2</TD><TD>3</TD><TD>481227</TD></TR><TR><TD>D</TD><TD>1</TD><TD>D2</TD><TD>4</TD><TD>413664</TD></TR><TR><TD>D</TD><TD>1</TD><TD>D2</TD><TD>5</TD><TD>430914</TD></TR><TR><TD>D</TD><TD>1+2</TD><TD>D2</TD><TD>1</TD><TD>278262</TD></TR><TR><TD>D</TD><TD>1+2</TD><TD>D2</TD><TD>2</TD><TD>286955</TD></TR><TR><TD>D</TD><TD>1+2</TD><TD>D2</TD><TD>3</TD><TD>226982</TD></TR><TR><TD>D</TD><TD>1+2</TD><TD>D2</TD><TD>4</TD><TD>258981</TD></TR><TR><TD>D</TD><TD>1+2</TD><TD>D2</TD><TD>5</TD><TD>268785</TD></TR><TR><TD>D</TD><TD>1+2+3</TD><TD>D2</TD><TD>1</TD><TD>236513</TD></TR><TR><TD>D</TD><TD>1+2+3</TD><TD>D2</TD><TD>2</TD><TD>210532</TD></TR><TR><TD>D</TD><TD>1+2+3</TD><TD>D2</TD><TD>3</TD><TD>156137</TD></TR><TR><TD>D</TD><TD>1+2+3</TD><TD>D2</TD><TD>4</TD><TD>119717</TD></TR><TR><TD>D</TD><TD>1+2+3</TD><TD>D2</TD><TD>5</TD><TD>151279</TD></TR><TR><TD>D</TD><TD>1+3</TD><TD>D2</TD><TD>1</TD><TD>538222</TD></TR><TR><TD>D</TD><TD>1+3</TD><TD>D2</TD><TD>2</TD><TD>529583</TD></TR><TR><TD>D</TD><TD>1+3</TD><TD>D2</TD><TD>3</TD><TD>517925</TD></TR><TR><TD>D</TD><TD>1+3</TD><TD>D2</TD><TD>4</TD><TD>532973</TD></TR><TR><TD>D</TD><TD>1+3</TD><TD>D2</TD><TD>5</TD><TD>530916</TD></TR><TR><TD>D</TD><TD>1</TD><TD>D3</TD><TD>1</TD><TD>496014</TD></TR><TR><TD>D</TD><TD>1</TD><TD>D3</TD><TD>2</TD><TD>419344</TD></TR><TR><TD>D</TD><TD>1</TD><TD>D3</TD><TD>3</TD><TD>468740</TD></TR><TR><TD>D</TD><TD>1</TD><TD>D3</TD><TD>4</TD><TD>470809</TD></TR><TR><TD>D</TD><TD>1</TD><TD>D3</TD><TD>5</TD><TD>484953</TD></TR><TR><TD>D</TD><TD>1+2</TD><TD>D3</TD><TD>1</TD><TD>712583</TD></TR><TR><TD>D</TD><TD>1+2</TD><TD>D3</TD><TD>2</TD><TD>634273</TD></TR><TR><TD>D</TD><TD>1+2</TD><TD>D3</TD><TD>3</TD><TD>654884</TD></TR><TR><TD>D</TD><TD>1+2</TD><TD>D3</TD><TD>4</TD><TD>664783</TD></TR><TR><TD>D</TD><TD>1+2</TD><TD>D3</TD><TD>5</TD><TD>676842</TD></TR><TR><TD>D</TD><TD>1+2+3</TD><TD>D3</TD><TD>1</TD><TD>456312</TD></TR><TR><TD>D</TD><TD>1+2+3</TD><TD>D3</TD><TD>2</TD><TD>424410</TD></TR><TR><TD>D</TD><TD>1+2+3</TD><TD>D3</TD><TD>3</TD><TD>440612</TD></TR><TR><TD>D</TD><TD>1+2+3</TD><TD>D3</TD><TD>4</TD><TD>416622</TD></TR><TR><TD>D</TD><TD>1+2+3</TD><TD>D3</TD><TD>5</TD><TD>438208</TD></TR><TR><TD>D</TD><TD>1+3</TD><TD>D3</TD><TD>1</TD><TD>693942</TD></TR><TR><TD>D</TD><TD>1+3</TD><TD>D3</TD><TD>2</TD><TD>691170</TD></TR><TR><TD>D</TD><TD>1+3</TD><TD>D3</TD><TD>3</TD><TD>629976</TD></TR><TR><TD>D</TD><TD>1+3</TD><TD>D3</TD><TD>4</TD><TD>698913</TD></TR><TR><TD>D</TD><TD>1+3</TD><TD>D3</TD><TD>5</TD><TD>769643</TD></TR><TR><TD>D</TD><TD>1</TD><TD>D4</TD><TD>1</TD><TD>427913</TD></TR><TR><TD>D</TD><TD>1</TD><TD>D4</TD><TD>2</TD><TD>419932</TD></TR><TR><TD>D</TD><TD>1</TD><TD>D4</TD><TD>3</TD><TD>397815</TD></TR><TR><TD>D</TD><TD>1</TD><TD>D4</TD><TD>4</TD><TD>399724</TD></TR><TR><TD>D</TD><TD>1</TD><TD>D4</TD><TD>5</TD><TD>399517</TD></TR><TR><TD>D</TD><TD>1+2</TD><TD>D4</TD><TD>1</TD><TD>511499</TD></TR><TR><TD>D</TD><TD>1+2</TD><TD>D4</TD><TD>2</TD><TD>460973</TD></TR><TR><TD>D</TD><TD>1+2</TD><TD>D4</TD><TD>3</TD><TD>422244</TD></TR><TR><TD>D</TD><TD>1+2</TD><TD>D4</TD><TD>4</TD><TD>559974</TD></TR><TR><TD>D</TD><TD>1+2</TD><TD>D4</TD><TD>5</TD><TD>518275</TD></TR><TR><TD>D</TD><TD>1+2+3</TD><TD>D4</TD><TD>1</TD><TD>448751</TD></TR><TR><TD>D</TD><TD>1+2+3</TD><TD>D4</TD><TD>2</TD><TD>375320</TD></TR><TR><TD>D</TD><TD>1+2+3</TD><TD>D4</TD><TD>3</TD><TD>417325</TD></TR><TR><TD>D</TD><TD>1+2+3</TD><TD>D4</TD><TD>4</TD><TD>327513</TD></TR><TR><TD>D</TD><TD>1+2+3</TD><TD>D4</TD><TD>5</TD><TD>327415</TD></TR><TR><TD>D</TD><TD>1+3</TD><TD>D4</TD><TD>1</TD><TD>598966</TD></TR><TR><TD>D</TD><TD>1+3</TD><TD>D4</TD><TD>2</TD><TD>593115</TD></TR><TR><TD>D</TD><TD>1+3</TD><TD>D4</TD><TD>3</TD><TD>537046</TD></TR><TR><TD>D</TD><TD>1+3</TD><TD>D4</TD><TD>4</TD><TD>588924</TD></TR><TR><TD>D</TD><TD>1+3</TD><TD>D4</TD><TD>5</TD><TD>568589</TD></TR><TR><TD>D</TD><TD>1</TD><TD>D5</TD><TD>1</TD><TD>452302</TD></TR><TR><TD>D</TD><TD>1</TD><TD>D5</TD><TD>2</TD><TD>295407</TD></TR><TR><TD>D</TD><TD>1</TD><TD>D5</TD><TD>3</TD><TD>443580</TD></TR><TR><TD>D</TD><TD>1</TD><TD>D5</TD><TD>4</TD><TD>380202</TD></TR><TR><TD>D</TD><TD>1</TD><TD>D5</TD><TD>5</TD><TD>342135</TD></TR><TR><TD>D</TD><TD>1+2</TD><TD>D5</TD><TD>1</TD><TD>526964</TD></TR><TR><TD>D</TD><TD>1+2</TD><TD>D5</TD><TD>2</TD><TD>513785</TD></TR><TR><TD>D</TD><TD>1+2</TD><TD>D5</TD><TD>3</TD><TD>485871</TD></TR><TR><TD>D</TD><TD>1+2</TD><TD>D5</TD><TD>4</TD><TD>493392</TD></TR><TR><TD>D</TD><TD>1+2</TD><TD>D5</TD><TD>5</TD><TD>428953</TD></TR><TR><TD>D</TD><TD>1+2+3</TD><TD>D5</TD><TD>1</TD><TD>290895</TD></TR><TR><TD>D</TD><TD>1+2+3</TD><TD>D5</TD><TD>2</TD><TD>304773</TD></TR><TR><TD>D</TD><TD>1+2+3</TD><TD>D5</TD><TD>3</TD><TD>233861</TD></TR><TR><TD>D</TD><TD>1+2+3</TD><TD>D5</TD><TD>4</TD><TD>239263</TD></TR><TR><TD>D</TD><TD>1+2+3</TD><TD>D5</TD><TD>5</TD><TD>204572</TD></TR><TR><TD>D</TD><TD>1+3</TD><TD>D5</TD><TD>1</TD><TD>561195</TD></TR><TR><TD>D</TD><TD>1+3</TD><TD>D5</TD><TD>2</TD><TD>563376</TD></TR><TR><TD>D</TD><TD>1+3</TD><TD>D5</TD><TD>3</TD><TD>552295</TD></TR><TR><TD>D</TD><TD>1+3</TD><TD>D5</TD><TD>4</TD><TD>542625</TD></TR><TR><TD>D</TD><TD>1+3</TD><TD>D5</TD><TD>5</TD><TD>550423</TD></TR><TR><TD>D</TD><TD>1</TD><TD>D6</TD><TD>1</TD><TD>151525</TD></TR><TR><TD>D</TD><TD>1</TD><TD>D6</TD><TD>2</TD><TD>140694</TD></TR><TR><TD>D</TD><TD>1</TD><TD>D6</TD><TD>3</TD><TD>151348</TD></TR><TR><TD>D</TD><TD>1</TD><TD>D6</TD><TD>4</TD><TD>140498</TD></TR><TR><TD>D</TD><TD>1</TD><TD>D6</TD><TD>5</TD><TD>132310</TD></TR><TR><TD>D</TD><TD>1+2</TD><TD>D6</TD><TD>1</TD><TD>324575</TD></TR><TR><TD>D</TD><TD>1+2</TD><TD>D6</TD><TD>2</TD><TD>323197</TD></TR><TR><TD>D</TD><TD>1+2</TD><TD>D6</TD><TD>3</TD><TD>316585</TD></TR><TR><TD>D</TD><TD>1+2</TD><TD>D6</TD><TD>4</TD><TD>284173</TD></TR><TR><TD>D</TD><TD>1+2</TD><TD>D6</TD><TD>5</TD><TD>312782</TD></TR><TR><TD>D</TD><TD>1+2+3</TD><TD>D6</TD><TD>1</TD><TD>123533</TD></TR><TR><TD>D</TD><TD>1+2+3</TD><TD>D6</TD><TD>2</TD><TD>121773</TD></TR><TR><TD>D</TD><TD>1+2+3</TD><TD>D6</TD><TD>3</TD><TD>121476</TD></TR><TR><TD>D</TD><TD>1+2+3</TD><TD>D6</TD><TD>4</TD><TD>120766</TD></TR><TR><TD>D</TD><TD>1+2+3</TD><TD>D6</TD><TD>5</TD><TD>121636</TD></TR><TR><TD>D</TD><TD>1+3</TD><TD>D6</TD><TD>1</TD><TD>314985</TD></TR><TR><TD>D</TD><TD>1+3</TD><TD>D6</TD><TD>2</TD><TD>309984</TD></TR><TR><TD>D</TD><TD>1+3</TD><TD>D6</TD><TD>3</TD><TD>288682</TD></TR><TR><TD>D</TD><TD>1+3</TD><TD>D6</TD><TD>4</TD><TD>295393</TD></TR><TR><TD>D</TD><TD>1+3</TD><TD>D6</TD><TD>5</TD><TD>285891</TD></TR><TR><TD>D</TD><TD>1</TD><TD>D7</TD><TD>1</TD><TD>231758</TD></TR><TR><TD>D</TD><TD>1</TD><TD>D7</TD><TD>2</TD><TD>238973</TD></TR><TR><TD>D</TD><TD>1</TD><TD>D7</TD><TD>3</TD><TD>252995</TD></TR><TR><TD>D</TD><TD>1</TD><TD>D7</TD><TD>4</TD><TD>184888</TD></TR><TR><TD>D</TD><TD>1</TD><TD>D7</TD><TD>5</TD><TD>203697</TD></TR><TR><TD>D</TD><TD>1+2</TD><TD>D7</TD><TD>1</TD><TD>150338</TD></TR><TR><TD>D</TD><TD>1+2</TD><TD>D7</TD><TD>2</TD><TD>143496</TD></TR><TR><TD>D</TD><TD>1+2</TD><TD>D7</TD><TD>3</TD><TD>143558</TD></TR><TR><TD>D</TD><TD>1+2</TD><TD>D7</TD><TD>4</TD><TD>140278</TD></TR><TR><TD>D</TD><TD>1+2</TD><TD>D7</TD><TD>5</TD><TD>140189</TD></TR><TR><TD>D</TD><TD>1+2+3</TD><TD>D7</TD><TD>1</TD><TD>237055</TD></TR><TR><TD>D</TD><TD>1+2+3</TD><TD>D7</TD><TD>2</TD><TD>260468</TD></TR><TR><TD>D</TD><TD>1+2+3</TD><TD>D7</TD><TD>3</TD><TD>247947</TD></TR><TR><TD>D</TD><TD>1+2+3</TD><TD>D7</TD><TD>4</TD><TD>241240</TD></TR><TR><TD>D</TD><TD>1+2+3</TD><TD>D7</TD><TD>5</TD><TD>217081</TD></TR><TR><TD>D</TD><TD>1+3</TD><TD>D7</TD><TD>1</TD><TD>229403</TD></TR><TR><TD>D</TD><TD>1+3</TD><TD>D7</TD><TD>2</TD><TD>216481</TD></TR><TR><TD>D</TD><TD>1+3</TD><TD>D7</TD><TD>3</TD><TD>198361</TD></TR><TR><TD>D</TD><TD>1+3</TD><TD>D7</TD><TD>4</TD><TD>207942</TD></TR><TR><TD>D</TD><TD>1+3</TD><TD>D7</TD><TD>5</TD><TD>217733</TD></TR><TR><TD>D</TD><TD>1</TD><TD>D8</TD><TD>1</TD><TD>528971</TD></TR><TR><TD>D</TD><TD>1</TD><TD>D8</TD><TD>2</TD><TD>493396</TD></TR><TR><TD>D</TD><TD>1</TD><TD>D8</TD><TD>3</TD><TD>498951</TD></TR><TR><TD>D</TD><TD>1</TD><TD>D8</TD><TD>4</TD><TD>480924</TD></TR><TR><TD>D</TD><TD>1</TD><TD>D8</TD><TD>5</TD><TD>497756</TD></TR><TR><TD>D</TD><TD>1+2</TD><TD>D8</TD><TD>1</TD><TD>500988</TD></TR><TR><TD>D</TD><TD>1+2</TD><TD>D8</TD><TD>2</TD><TD>352342</TD></TR><TR><TD>D</TD><TD>1+2</TD><TD>D8</TD>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2</TD><TD>296417</TD></TR><TR><TD>D</TD><TD>1</TD><TD>D12</TD><TD>3</TD><TD>250726</TD></TR><TR><TD>D</TD><TD>1</TD><TD>D12</TD><TD>4</TD><TD>308349</TD></TR><TR><TD>D</TD><TD>1</TD><TD>D12</TD><TD>5</TD><TD>248071</TD></TR><TR><TD>D</TD><TD>1+2</TD><TD>D12</TD><TD>1</TD><TD>163460</TD></TR><TR><TD>D</TD><TD>1+2</TD><TD>D12</TD><TD>2</TD><TD>148729</TD></TR><TR><TD>D</TD><TD>1+2</TD><TD>D12</TD><TD>3</TD><TD>159533</TD></TR><TR><TD>D</TD><TD>1+2</TD><TD>D12</TD><TD>4</TD><TD>139568</TD></TR><TR><TD>D</TD><TD>1+2</TD><TD>D12</TD><TD>5</TD><TD>151676</TD></TR><TR><TD>D</TD><TD>1+2+3</TD><TD>D12</TD><TD>1</TD><TD>79323</TD></TR><TR><TD>D</TD><TD>1+2+3</TD><TD>D12</TD><TD>2</TD><TD>76269</TD></TR><TR><TD>D</TD><TD>1+2+3</TD><TD>D12</TD><TD>3</TD><TD>78035</TD></TR><TR><TD>D</TD><TD>1+2+3</TD><TD>D12</TD><TD>4</TD><TD>75395</TD></TR><TR><TD>D</TD><TD>1+2+3</TD><TD>D12</TD><TD>5</TD><TD>78143</TD></TR><TR><TD>D</TD><TD>1+3</TD><TD>D12</TD><TD>1</TD><TD>626971</TD></TR><TR><TD>D</TD><TD>1+3</TD><TD>D12</TD><TD>2</TD><TD>553892</TD></TR><TR><TD>D</TD><TD>1+3</TD><TD>D12</TD><TD>3</TD><TD>594874</TD></TR><TR><TD>D</TD><TD>1+3</TD><TD>D12</TD><TD>4</TD><TD>570093</TD></TR><TR><TD>D</TD><TD>1+3</TD><TD>D12</TD><TD>5</TD><TD>586996</TD></TR><TR><TD>ctrl</TD><TD>1</TD><TD>C1</TD><TD>1</TD><TD>86962</TD></TR><TR><TD>ctrl</TD><TD>1</TD><TD>C1</TD><TD>2</TD><TD>78238</TD></TR><TR><TD>ctrl</TD><TD>1</TD><TD>C1</TD><TD>3</TD><TD>73522</TD></TR><TR><TD>ctrl</TD><TD>1</TD><TD>C1</TD><TD>4</TD><TD>73355</TD></TR><TR><TD>ctrl</TD><TD>1</TD><TD>C1</TD><TD>5</TD><TD>69748</TD></TR><TR><TD>ctrl</TD><TD>1+2</TD><TD>C1</TD><TD>1</TD><TD>98594</TD></TR><TR><TD>ctrl</TD><TD>1+2</TD><TD>C1</TD><TD>2</TD><TD>137487</TD></TR><TR><TD>ctrl</TD><TD>1+2</TD><TD>C1</TD><TD>3</TD><TD>124254</TD></TR><TR><TD>ctrl</TD><TD>1+2</TD><TD>C1</TD><TD>4</TD><TD>158471</TD></TR><TR><TD>ctrl</TD><TD>1+2</TD><TD>C1</TD><TD>5</TD><TD>92564</TD></TR><TR><TD>ctrl</TD><TD>1+2+3</TD><TD>C1</TD><TD>1</TD><TD>66288</TD></TR><TR><TD>ctrl</TD><TD>1+2+3</TD><TD>C1</TD><TD>2</TD><TD>59785</TD></TR><TR><TD>ctrl</TD><TD>1+2+3</TD><TD>C1</TD><TD>3</TD><TD>52898</TD></TR><TR><TD>ctrl</TD><TD>1+2+3</TD><TD>C1</TD><TD>4</TD><TD>47599</TD></TR><TR><TD>ctrl</TD><TD>1+2+3</TD><TD>C1</TD><TD>5</TD><TD>49859</TD></TR><TR><TD>ctrl</TD><TD>1+3</TD><TD>C1</TD><TD>1</TD><TD>62148</TD></TR><TR><TD>ctrl</TD><TD>1+3</TD><TD>C1</TD><TD>2</TD><TD>71232</TD></TR><TR><TD>ctrl</TD><TD>1+3</TD><TD>C1</TD><TD>3</TD><TD>65424</TD></TR><TR><TD>ctrl</TD><TD>1+3</TD><TD>C1</TD><TD>4</TD><TD>59534</TD></TR><TR><TD>ctrl</TD><TD>1+3</TD><TD>C1</TD><TD>5</TD><TD>62532</TD></TR><TR><TD>ctrl</TD><TD>1</TD><TD>C2</TD><TD>1</TD><TD>91041</TD></TR><TR><TD>ctrl</TD><TD>1</TD><TD>C2</TD><TD>2</TD><TD>93555</TD></TR><TR><TD>ctrl</TD><TD>1</TD><TD>C2</TD><TD>3</TD><TD>93478</TD></TR><TR><TD>ctrl</TD><TD>1</TD><TD>C2</TD><TD>4</TD><TD>89325</TD></TR><TR><TD>ctrl</TD><TD>1</TD><TD>C2</TD><TD>5</TD><TD>92847</TD></TR><TR><TD>ctrl</TD><TD>1+2</TD><TD>C2</TD><TD>1</TD><TD>60630</TD></TR><TR><TD>ctrl</TD><TD>1+2</TD><TD>C2</TD><TD>2</TD><TD>59552</TD></TR><TR><TD>ctrl</TD><TD>1+2</TD><TD>C2</TD><TD>3</TD><TD>60105</TD></TR><TR><TD>ctrl</TD><TD>1+2</TD><TD>C2</TD><TD>4</TD><TD>61149</TD></TR><TR><TD>ctrl</TD><TD>1+2</TD><TD>C2</TD><TD>5</TD><TD>58308</TD></TR><TR><TD>ctrl</TD><TD>1+2+3</TD><TD>C2</TD><TD>1</TD><TD>83505</TD></TR><TR><TD>ctrl</TD><TD>1+2+3</TD><TD>C2</TD><TD>2</TD><TD>84301</TD></TR><TR><TD>ctrl</TD><TD>1+2+3</TD><TD>C2</TD><TD>3</TD><TD>83447</TD></TR><TR><TD>ctrl</TD><TD>1+2+3</TD><TD>C2</TD><TD>4</TD><TD>82376</TD></TR><TR><TD>ctrl</TD><TD>1+2+3</TD><TD>C2</TD><TD>5</TD><TD>84744</TD></TR><TR><TD>ctrl</TD><TD>1+3</TD><TD>C2</TD><TD>1</TD><TD>83488</TD></TR><TR><TD>ctrl</TD><TD>1+3</TD><TD>C2</TD><TD>2</TD><TD>80861</TD></TR><TR><TD>ctrl</TD><TD>1+3</TD><TD>C2</TD><TD>3</TD><TD>83690</TD></TR><TR><TD>ctrl</TD><TD>1+3</TD><TD>C2</TD><TD>4</TD><TD>83577</TD></TR><TR><TD>ctrl</TD><TD>1+3</TD><TD>C2</TD><TD>5</TD><TD>82614</TD></TR><TR><TD>ctrl</TD><TD>1</TD><TD>C3</TD><TD>1</TD><TD>130417</TD></TR><TR><TD>ctrl</TD><TD>1</TD><TD>C3</TD><TD>2</TD><TD>124647</TD></TR><TR><TD>ctrl</TD><TD>1</TD><TD>C3</TD><TD>3</TD><TD>130866</TD></TR><TR><TD>ctrl</TD><TD>1</TD><TD>C3</TD><TD>4</TD><TD>131894</TD></TR><TR><TD>ctrl</TD><TD>1</TD><TD>C3</TD><TD>5</TD><TD>129993</TD></TR><TR><TD>ctrl</TD><TD>1+2</TD><TD>C3</TD><TD>1</TD><TD>131093</TD></TR><TR><TD>ctrl</TD><TD>1+2</TD><TD>C3</TD><TD>2</TD><TD>128174</TD></TR><TR><TD>ctrl</TD><TD>1+2</TD><TD>C3</TD><TD>3</TD><TD>130239</TD></TR><TR><TD>ctrl</TD><TD>1+2</TD><TD>C3</TD><TD>4</TD><TD>130141</TD></TR><TR><TD>ctrl</TD><TD>1+2</TD><TD>C3</TD><TD>5</TD><TD>129516</TD></TR><TR><TD>ctrl</TD><TD>1+2+3</TD><TD>C3</TD><TD>1</TD><TD>127552</TD></TR><TR><TD>ctrl</TD><TD>1+2+3</TD><TD>C3</TD><TD>2</TD><TD>125519</TD></TR><TR><TD>ctrl</TD><TD>1+2+3</TD><TD>C3</TD><TD>3</TD><TD>126711</TD></TR><TR><TD>ctrl</TD><TD>1+2+3</TD><TD>C3</TD><TD>4</TD><TD>129848</TD></TR><TR><TD>ctrl</TD><TD>1+2+3</TD><TD>C3</TD><TD>5</TD><TD>129213</TD></TR><TR><TD>ctrl</TD><TD>1+3</TD><TD>C3</TD><TD>1</TD><TD>113537</TD></TR><TR><TD>ctrl</TD><TD>1+3</TD><TD>C3</TD><TD>2</TD><TD>121609</TD></TR><TR><TD>ctrl</TD><TD>1+3</TD><TD>C3</TD><TD>3</TD><TD>111941</TD></TR><TR><TD>ctrl</TD><TD>1+3</TD><TD>C3</TD><TD>4</TD><TD>111000</TD></TR><TR><TD>ctrl</TD><TD>1+3</TD><TD>C3</TD><TD>5</TD><TD>114276</TD></TR><TR><TD>ctrl</TD><TD>1</TD><TD>C4</TD><TD>1</TD><TD>22301</TD></TR><TR><TD>ctrl</TD><TD>1</TD><TD>C4</TD><TD>2</TD><TD>24102</TD></TR><TR><TD>ctrl</TD><TD>1</TD><TD>C4</TD><TD>3</TD><TD>19101</TD></TR><TR><TD>ctrl</TD><TD>1</TD><TD>C4</TD><TD>4</TD><TD>38211</TD></TR><TR><TD>ctrl</TD><TD>1</TD><TD>C4</TD><TD>5</TD><TD>37794</TD></TR><TR><TD>ctrl</TD><TD>1+2</TD><TD>C4</TD><TD>1</TD><TD>71477</TD></TR><TR><TD>ctrl</TD><TD>1+2</TD><TD>C4</TD><TD>2</TD><TD>67638</TD></TR><TR><TD>ctrl</TD><TD>1+2</TD><TD>C4</TD><TD>3</TD><TD>81357</TD></TR><TR><TD>ctrl</TD><TD>1+2</TD><TD>C4</TD><TD>4</TD><TD>47137</TD></TR><TR><TD>ctrl</TD><TD>1+2</TD><TD>C4</TD><TD>5</TD><TD>54535</TD></TR><TR><TD>ctrl</TD><TD>1+2+3</TD><TD>C4</TD><TD>1</TD><TD>42178</TD></TR><TR><TD>ctrl</TD><TD>1+2+3</TD><TD>C4</TD><TD>2</TD><TD>51847</TD></TR><TR><TD>ctrl</TD><TD>1+2+3</TD><TD>C4</TD><TD>3</TD><TD>39032</TD></TR><TR><TD>ctrl</TD><TD>1+2+3</TD><TD>C4</TD><TD>4</TD><TD>37201</TD></TR><TR><TD>ctrl</TD><TD>1+2+3</TD><TD>C4</TD><TD>5</TD><TD>37153</TD></TR><TR><TD>ctrl</TD><TD>1+3</TD><TD>C4</TD><TD>1</TD><TD>83592</TD></TR><TR><TD>ctrl</TD><TD>1+3</TD><TD>C4</TD><TD>2</TD><TD>77168</TD></TR><TR><TD>ctrl</TD><TD>1+3</TD><TD>C4</TD><TD>3</TD><TD>65752</TD></TR><TR><TD>ctrl</TD><TD>1+3</TD><TD>C4</TD><TD>4</TD><TD>73187</TD></TR><TR><TD>ctrl</TD><TD>1+3</TD><TD>C4</TD><TD>5</TD><TD>54966</TD></TR><TR><TD>ctrl</TD><TD>1</TD><TD>C5</TD><TD>1</TD><TD>12983</TD></TR><TR><TD>ctrl</TD><TD>1</TD><TD>C5</TD><TD>2</TD><TD>340907</TD></TR><TR><TD>ctrl</TD><TD>1</TD><TD>C5</TD><TD>3</TD><TD>114244</TD></TR><TR><TD>ctrl</TD><TD>1</TD><TD>C5</TD><TD>4</TD><TD>128359</TD></TR><TR><TD>ctrl</TD><TD>1</TD><TD>C5</TD><TD>5</TD><TD>18443</TD></TR><TR><TD>ctrl</TD><TD>1+2</TD><TD>C5</TD><TD>1</TD><TD>72999</TD></TR><TR><TD>ctrl</TD><TD>1+2</TD><TD>C5</TD><TD>2</TD><TD>54537</TD></TR><TR><TD>ctrl</TD><TD>1+2</TD><TD>C5</TD><TD>3</TD><TD>59254</TD></TR><TR><TD>ctrl</TD><TD>1+2</TD><TD>C5</TD><TD>4</TD><TD>38272</TD></TR><TR><TD>ctrl</TD><TD>1+2</TD><TD>C5</TD><TD>5</TD><TD>38254</TD></TR><TR><TD>ctrl</TD><TD>1+2+3</TD><TD>C5</TD><TD>1</TD><TD>82657</TD></TR><TR><TD>ctrl</TD><TD>1+2+3</TD><TD>C5</TD><TD>2</TD><TD>71214</TD></TR><TR><TD>ctrl</TD><TD>1+2+3</TD><TD>C5</TD><TD>3</TD><TD>52381</TD></TR><TR><TD>ctrl</TD><TD>1+2+3</TD><TD>C5</TD><TD>4</TD><TD>32244</TD></TR><TR><TD>ctrl</TD><TD>1+2+3</TD><TD>C5</TD><TD>5</TD><TD>48865</TD></TR><TR><TD>ctrl</TD><TD>1+3</TD><TD>C5</TD><TD>1</TD><TD>71562</TD></TR><TR><TD>ctrl</TD><TD>1+3</TD><TD>C5</TD><TD>2</TD><TD>64598</TD></TR><TR><TD>ctrl</TD><TD>1+3</TD><TD>C5</TD><TD>3</TD><TD>79327</TD></TR><TR><TD>ctrl</TD><TD>1+3</TD><TD>C5</TD><TD>4</TD><TD>38258</TD></TR><TR><TD>ctrl</TD><TD>1+3</TD><TD>C5</TD><TD>5</TD><TD>48368</TD></TR><TR><TD>ctrl</TD><TD>1</TD><TD>C6</TD><TD>1</TD><TD>63305</TD></TR><TR><TD>ctrl</TD><TD>1</TD><TD>C6</TD><TD>2</TD><TD>63293</TD></TR><TR><TD>ctrl</TD><TD>1</TD><TD>C6</TD><TD>3</TD><TD>64925</TD></TR><TR><TD>ctrl</TD><TD>1</TD><TD>C6</TD><TD>4</TD><TD>64381</TD></TR><TR><TD>ctrl</TD><TD>1</TD><TD>C6</TD><TD>5</TD><TD>66729</TD></TR><TR><TD>ctrl</TD><TD>1+2</TD><TD>C6</TD><TD>1</TD><TD>86144</TD></TR><TR><TD>ctrl</TD><TD>1+2</TD><TD>C6</TD><TD>2</TD><TD>83301</TD></TR><TR><TD>ctrl</TD><TD>1+2</TD><TD>C6</TD><TD>3</TD><TD>84701</TD></TR><TR><TD>ctrl</TD><TD>1+2</TD><TD>C6</TD><TD>4</TD><TD>87144</TD></TR><TR><TD>ctrl</TD><TD>1+2</TD><TD>C6</TD><TD>5</TD><TD>82177</TD></TR><TR><TD>ctrl</TD><TD>1+2+3</TD><TD>C6</TD><TD>1</TD><TD>98863</TD></TR><TR><TD>ctrl</TD><TD>1+2+3</TD><TD>C6</TD><TD>2</TD><TD>98377</TD></TR><TR><TD>ctrl</TD><TD>1+2+3</TD><TD>C6</TD><TD>3</TD><TD>100403</TD></TR><TR><TD>ctrl</TD><TD>1+2+3</TD><TD>C6</TD><TD>4</TD><TD>100291</TD></TR><TR><TD>ctrl</TD><TD>1+2+3</TD><TD>C6</TD><TD>5</TD><TD>100793</TD></TR><TR><TD>ctrl</TD><TD>1+3</TD><TD>C6</TD><TD>1</TD><TD>94011</TD></TR><TR><TD>ctrl</TD><TD>1+3</TD><TD>C6</TD><TD>2</TD><TD>86967</TD></TR><TR><TD>ctrl</TD><TD>1+3</TD><TD>C6</TD><TD>3</TD><TD>93922</TD></TR><TR><TD>ctrl</TD><TD>1+3</TD><TD>C6</TD><TD>4</TD><TD>92021</TD></TR><TR><TD>ctrl</TD><TD>1+3</TD><TD>C6</TD><TD>5</TD><TD>89911</TD></TR><TR><TD>ctrl</TD><TD>1</TD><TD>C7</TD><TD>1</TD><TD>119105</TD></TR><TR><TD>ctrl</TD><TD>1</TD><TD>C7</TD><TD>2</TD><TD>121940</TD></TR><TR><TD>ctrl</TD><TD>1</TD><TD>C7</TD><TD>3</TD><TD>116700</TD></TR><TR><TD>ctrl</TD><TD>1</TD><TD>C7</TD><TD>4</TD><TD>122114</TD></TR><TR><TD>ctrl</TD><TD>1</TD><TD>C7</TD><TD>5</TD><TD>115009</TD></TR><TR><TD>ctrl</TD><TD>1+2</TD><TD>C7</TD><TD>1</TD><TD>110396</TD></TR><TR><TD>ctrl</TD><TD>1+2</TD><TD>C7</TD><TD>2</TD><TD>115510</TD></TR><TR><TD>ctrl</TD><TD>1+2</TD><TD>C7</TD><TD>3</TD><TD>111504</TD></TR><TR><TD>ctrl</TD><TD>1+2</TD><TD>C7</TD><TD>4</TD><TD>110784</TD></TR><TR><TD>ctrl</TD><TD>1+2</TD><TD>C7</TD><TD>5</TD><TD>109219</TD></TR><TR><TD>ctrl</TD><TD>1+2+3</TD><TD>C7</TD><TD>1</TD><TD>196448</TD></TR><TR><TD>ctrl</TD><TD>1+2+3</TD><TD>C7</TD><TD>2</TD><TD>196720</TD></TR><TR><TD>ctrl</TD><TD>1+2+3</TD><TD>C7</TD><TD>3</TD><TD>197428</TD></TR><TR><TD>ctrl</TD><TD>1+2+3</TD><TD>C7</TD><TD>4</TD><TD>199719</TD></TR><TR><TD>ctrl</TD><TD>1+2+3</TD><TD>C7</TD><TD>5</TD><TD>192063</TD></TR><TR><TD>ctrl</TD><TD>1+3</TD><TD>C7</TD><TD>1</TD><TD>224785</TD></TR><TR><TD>ctrl</TD><TD>1+3</TD><TD>C7</TD><TD>2</TD><TD>225851</TD></TR><TR><TD>ctrl</TD><TD>1+3</TD><TD>C7</TD><TD>3</TD><TD>221603</TD></TR><TR><TD>ctrl</TD><TD>1+3</TD><TD>C7</TD><TD>4</TD><TD>220562</TD></TR><TR><TD>ctrl</TD><TD>1+3</TD><TD>C7</TD><TD>5</TD><TD>221109</TD></TR><TR><TD>ctrl</TD><TD>1</TD><TD>C8</TD><TD>1</TD><TD>89047</TD></TR><TR><TD>ctrl</TD><TD>1</TD><TD>C8</TD><TD>2</TD><TD>87179</TD></TR><TR><TD>ctrl</TD><TD>1</TD><TD>C8</TD><TD>3</TD><TD>87487</TD></TR><TR><TD>ctrl</TD><TD>1</TD><TD>C8</TD><TD>4</TD><TD>90849</TD></TR><TR><TD>ctrl</TD><TD>1</TD><TD>C8</TD><TD>5</TD><TD>88516</TD></TR><TR><TD>ctrl</TD><TD>1+2</TD><TD>C8</TD><TD>1</TD><TD>162359</TD></TR><TR><TD>ctrl</TD><TD>1+2</TD><TD>C8</TD><TD>2</TD><TD>156512</TD></TR><TR><TD>ctrl</TD><TD>1+2</TD><TD>C8</TD><TD>3</TD><TD>162665</TD></TR><TR><TD>ctrl</TD><TD>1+2</TD><TD>C8</TD><TD>4</TD><TD>168540</TD></TR><TR><TD>ctrl</TD><TD>1+2</TD><TD>C8</TD><TD>5</TD><TD>169213</TD></TR><TR><TD>ctrl</TD><TD>1+2+3</TD><TD>C8</TD><TD>1</TD><TD>79459</TD></TR><TR><TD>ctrl</TD><TD>1+2+3</TD><TD>C8</TD><TD>2</TD><TD>78650</TD></TR><TR><TD>ctrl</TD><TD>1+2+3</TD><TD>C8</TD><TD>3</TD><TD>79524</TD></TR><TR><TD>ctrl</TD><TD>1+2+3</TD><TD>C8</TD><TD>4</TD><TD>78989</TD></TR><TR><TD>ctrl</TD><TD>1+2+3</TD><TD>C8</TD><TD>5</TD><TD>79703</TD></TR><TR><TD>ctrl</TD><TD>1+3</TD><TD>C8</TD><TD>1</TD><TD>104540</TD></TR><TR><TD>ctrl</TD><TD>1+3</TD><TD>C8</TD><TD>2</TD><TD>99693</TD></TR><TR><TD>ctrl</TD><TD>1+3</TD><TD>C8</TD><TD>3</TD><TD>102779</TD></TR><TR><TD>ctrl</TD><TD>1+3</TD><TD>C8</TD><TD>4</TD><TD>101869</TD></TR><TR><TD>ctrl</TD><TD>1+3</TD><TD>C8</TD><TD>5</TD><TD>103001</TD></TR><TR><TD>ctrl</TD><TD>1</TD><TD>C9</TD><TD>1</TD><TD>82848</TD></TR><TR><TD>ctrl</TD><TD>1</TD><TD>C9</TD><TD>2</TD><TD>84812</TD></TR><TR><TD>ctrl</TD><TD>1</TD><TD>C9</TD><TD>3</TD><TD>83114</TD></TR><TR><TD>ctrl</TD><TD>1</TD><TD>C9</TD><TD>4</TD><TD>85284</TD></TR><TR><TD>ctrl</TD><TD>1</TD><TD>C9</TD><TD>5</TD><TD>82324</TD></TR><TR><TD>ctrl</TD><TD>1+2</TD><TD>C9</TD><TD>1</TD><TD>68911</TD></TR><TR><TD>ctrl</TD><TD>1+2</TD><TD>C9</TD><TD>2</TD><TD>67781</TD></TR><TR><TD>ctrl</TD><TD>1+2</TD><TD>C9</TD><TD>3</TD><TD>69592</TD></TR><TR><TD>ctrl</TD><TD>1+2</TD><TD>C9</TD><TD>4</TD><TD>67487</TD></TR><TR><TD>ctrl</TD><TD>1+2</TD><TD>C9</TD><TD>5</TD><TD>68789</TD></TR><TR><TD>ctrl</TD><TD>1+2+3</TD><TD>C9</TD><TD>1</TD><TD>73284</TD></TR><TR><TD>ctrl</TD><TD>1+2+3</TD><TD>C9</TD><TD>2</TD><TD>75162</TD></TR><TR><TD>ctrl</TD><TD>1+2+3</TD><TD>C9</TD><TD>3</TD><TD>73766</TD></TR><TR><TD>ctrl</TD><TD>1+2+3</TD><TD>C9</TD><TD>4</TD><TD>74591</TD></TR><TR><TD>ctrl</TD><TD>1+2+3</TD><TD>C9</TD><TD>5</TD><TD>75591</TD></TR><TR><TD>ctrl</TD><TD>1+3</TD><TD>C9</TD><TD>1</TD><TD>50998</TD></TR><TR><TD>ctrl</TD><TD>1+3</TD><TD>C9</TD><TD>2</TD><TD>49504</TD></TR><TR><TD>ctrl</TD><TD>1+3</TD><TD>C9</TD><TD>3</TD><TD>51023</TD></TR><TR><TD>ctrl</TD><TD>1+3</TD><TD>C9</TD><TD>4</TD><TD>50558</TD></TR><TR><TD>ctrl</TD><TD>1+3</TD><TD>C9</TD><TD>5</TD><TD>50159</TD></TR><TR><TD>ctrl</TD><TD>1</TD><TD>C10</TD><TD>1</TD><TD>92934</TD></TR><TR><TD>ctrl</TD><TD>1</TD><TD>C10</TD><TD>2</TD><TD>96397</TD></TR><TR><TD>ctrl</TD><TD>1</TD><TD>C10</TD><TD>3</TD><TD>100353</TD></TR><TR><TD>ctrl</TD><TD>1</TD><TD>C10</TD><TD>4</TD><TD>97318</TD></TR><TR><TD>ctrl</TD><TD>1</TD><TD>C10</TD><TD>5</TD><TD>92684</TD></TR><TR><TD>ctrl</TD><TD>1+2</TD><TD>C10</TD><TD>1</TD><TD>175796</TD></TR><TR><TD>ctrl</TD><TD>1+2</TD><TD>C10</TD><TD>2</TD><TD>175960</TD></TR><TR><TD>ctrl</TD><TD>1+2</TD><TD>C10</TD><TD>3</TD><TD>177130</TD></TR><TR><TD>ctrl</TD><TD>1+2</TD><TD>C10</TD><TD>4</TD><TD>176969</TD></TR><TR><TD>ctrl</TD><TD>1+2</TD><TD>C10</TD><TD>5</TD><TD>172057</TD></TR><TR><TD>ctrl</TD><TD>1+2+3</TD><TD>C10</TD><TD>1</TD><TD>299139</TD></TR><TR><TD>ctrl</TD><TD>1+2+3</TD><TD>C10</TD><TD>2</TD><TD>295258</TD></TR><TR><TD>ctrl</TD><TD>1+2+3</TD><TD>C10</TD><TD>3</TD><TD>292623</TD></TR><TR><TD>ctrl</TD><TD>1+2+3</TD><TD>C10</TD><TD>4</TD><TD>296571</TD></TR><TR><TD>ctrl</TD><TD>1+2+3</TD><TD>C10</TD><TD>5</TD><TD>301145</TD></TR><TR><TD>ctrl</TD><TD>1+3</TD><TD>C10</TD><TD>1</TD><TD>130747</TD></TR><TR><TD>ctrl</TD><TD>1+3</TD><TD>C10</TD><TD>2</TD><TD>135256</TD></TR><TR><TD>ctrl</TD><TD>1+3</TD><TD>C10</TD><TD>3</TD><TD>130535</TD></TR><TR><TD>ctrl</TD><TD>1+3</TD><TD>C10</TD><TD>4</TD><TD>131637</TD></TR><TR><TD>ctrl</TD><TD>1+3</TD><TD>C10</TD><TD>5</TD><TD>134188</TD></TR><TR><TD>ctrl</TD><TD>1</TD><TD>C11</TD><TD>1</TD><TD>94395</TD></TR><TR><TD>ctrl</TD><TD>1</TD><TD>C11</TD><TD>2</TD><TD>93207</TD></TR><TR><TD>ctrl</TD><TD>1</TD><TD>C11</TD><TD>3</TD><TD>95727</TD></TR><TR><TD>ctrl</TD><TD>1</TD><TD>C11</TD><TD>4</TD><TD>91878</TD></TR><TR><TD>ctrl</TD><TD>1</TD><TD>C11</TD><TD>5</TD><TD>92932</TD></TR><TR><TD>ctrl</TD><TD>1+2</TD><TD>C11</TD><TD>1</TD><TD>29672904</TD></TR><TR><TD>ctrl</TD><TD>1+2</TD><TD>C11</TD><TD>2</TD><TD>41261021</TD></TR><TR><TD>ctrl</TD><TD>1+2</TD><TD>C11</TD><TD>3</TD><TD>54014275</TD></TR><TR><TD>ctrl</TD><TD>1+2</TD><TD>C11</TD><TD>4</TD><TD>25077474</TD></TR><TR><TD>ctrl</TD><TD>1+2</TD><TD>C11</TD><TD>5</TD><TD>73583123</TD></TR><TR><TD>ctrl</TD><TD>1+2+3</TD><TD>C11</TD><TD>1</TD><TD>81872</TD></TR><TR><TD>ctrl</TD><TD>1+2+3</TD><TD>C11</TD><TD>2</TD><TD>82734</TD></TR><TR><TD>ctrl</TD><TD>1+2+3</TD><TD>C11</TD><TD>3</TD><TD>84131</TD></TR><TR><TD>ctrl</TD><TD>1+2+3</TD><TD>C11</TD><TD>4</TD><TD>84768</TD></TR><TR><TD>ctrl</TD><TD>1+2+3</TD><TD>C11</TD><TD>5</TD><TD>83909</TD></TR><TR><TD>ctrl</TD><TD>1+3</TD><TD>C11</TD><TD>1</TD><TD>43734</TD></TR><TR><TD>ctrl</TD><TD>1+3</TD><TD>C11</TD><TD>2</TD><TD>46370</TD></TR><TR><TD>ctrl</TD><TD>1+3</TD><TD>C11</TD><TD>3</TD><TD>43888</TD></TR><TR><TD>ctrl</TD><TD>1+3</TD><TD>C11</TD><TD>4</TD><TD>44855</TD></TR><TR><TD>ctrl</TD><TD>1+3</TD><TD>C11</TD><TD>5</TD><TD>43269</TD></TR><TR><TD>ctrl</TD><TD>1</TD><TD>C12</TD><TD>1</TD><TD>85789</TD></TR><TR><TD>ctrl</TD><TD>1</TD><TD>C12</TD><TD>2</TD><TD>84396</TD></TR><TR><TD>ctrl</TD><TD>1</TD><TD>C12</TD><TD>3</TD><TD>90814</TD></TR><TR><TD>ctrl</TD><TD>1</TD><TD>C12</TD><TD>4</TD><TD>87896</TD></TR><TR><TD>ctrl</TD><TD>1</TD><TD>C12</TD><TD>5</TD><TD>86842</TD></TR><TR><TD>ctrl</TD><TD>1+2</TD><TD>C12</TD><TD>1</TD><TD>34059</TD></TR><TR><TD>ctrl</TD><TD>1+2</TD><TD>C12</TD><TD>2</TD><TD>34206</TD></TR><TR><TD>ctrl</TD><TD>1+2</TD><TD>C12</TD><TD>3</TD><TD>34647</TD></TR><TR><TD>ctrl</TD><TD>1+2</TD><TD>C12</TD><TD>4</TD><TD>34310</TD></TR><TR><TD>ctrl</TD><TD>1+2</TD><TD>C12</TD><TD>5</TD><TD>35210</TD></TR><TR><TD>ctrl</TD><TD>1+2+3</TD><TD>C12</TD><TD>1</TD><TD>145572</TD></TR><TR><TD>ctrl</TD><TD>1+2+3</TD><TD>C12</TD><TD>2</TD><TD>143967</TD></TR><TR><TD>ctrl</TD><TD>1+2+3</TD><TD>C12</TD><TD>3</TD><TD>138577</TD></TR><TR><TD>ctrl</TD><TD>1+2+3</TD><TD>C12</TD><TD>4</TD><TD>144353</TD></TR><TR><TD>ctrl</TD><TD>1+2+3</TD><TD>C12</TD><TD>5</TD><TD>142404</TD></TR><TR><TD>ctrl</TD><TD>1+3</TD><TD>C12</TD><TD>1</TD><TD>83488</TD></TR><TR><TD>ctrl</TD><TD>1+3</TD><TD>C12</TD><TD>2</TD><TD>80861</TD></TR><TR><TD>ctrl</TD><TD>1+3</TD><TD>C12</TD><TD>3</TD><TD>83690</TD></TR><TR><TD>ctrl</TD><TD>1+3</TD><TD>C12</TD><TD>4</TD><TD>83577</TD></TR><TR><TD>ctrl</TD><TD>1+3</TD><TD>C12</TD><TD>5</TD><TD>82614</TD></TR></TBODY></TABLE> Mon, 16 Nov 2020 16:18:20 GMT https://communities.sas.com/t5/Statistical-Procedures/proc-mixed-between-and-within-factors/m-p/699203#M33724 ACF1 2020-11-16T16:18:20Z Re: proc mixed between and within factors https://communities.sas.com/t5/Statistical-Procedures/proc-mixed-between-and-within-factors/m-p/699487#M33736 <P>I tried a couple versions of this, but this code ran without error or warning, and gave the smallest AICC:</P> <PRE>proc glimmix data=one; class Group Compound Animal Repeat; value=signal/1000; model value = group|compound|repeat/ddfm=bw; random intercept/subject=animal; random repeat/residual subject=animal type=cs group=group*compound; covtest homogeneity; run;</PRE> <P>&nbsp;</P> <PRE><CODE class=" language-sas"></CODE></PRE> <P>&nbsp;This split plot analysis with heterogeneous variances by group*compound is the best I came up with.&nbsp; Comparisons of interest regarding group and compound can be obtained with an LSMEANS or LSMESTIMATE statement.</P> <P>&nbsp;</P> <P>SteveDenham</P> <P>&nbsp;</P> Tue, 17 Nov 2020 13:47:00 GMT https://communities.sas.com/t5/Statistical-Procedures/proc-mixed-between-and-within-factors/m-p/699487#M33736 SteveDenham 2020-11-17T13:47:00Z Re: proc mixed between and within factors https://communities.sas.com/t5/Statistical-Procedures/proc-mixed-between-and-within-factors/m-p/699564#M33737 <P>Thank you Steve, PROC GLIMMIX is very complicated and the model so! Is it possible to omit the "repeat" factor in the MODEL statement?</P> Tue, 17 Nov 2020 16:47:51 GMT https://communities.sas.com/t5/Statistical-Procedures/proc-mixed-between-and-within-factors/m-p/699564#M33737 ACF1 2020-11-17T16:47:51Z Re: proc mixed between and within factors https://communities.sas.com/t5/Statistical-Procedures/proc-mixed-between-and-within-factors/m-p/699601#M33738 <P>You can, but be sure to include the random statements as in the current model, especially the group=group*compound option to deal with the heterogeneity of variance issue.&nbsp; I don't know why you would drop it, though. It is a known design factor, the F tests, lsmeans and lsmean difference p values for tests of group, compound and group by compound are no different, and you get some insight into which whole plot factors have the largest effect on the repeat to repeat variability.</P> <P>&nbsp;</P> <P>SteveDenham</P> Tue, 17 Nov 2020 20:14:10 GMT https://communities.sas.com/t5/Statistical-Procedures/proc-mixed-between-and-within-factors/m-p/699601#M33738 SteveDenham 2020-11-17T20:14:10Z