topic the Kaplan-Meier estimate from Uno’s Concordance Statistic in Statistical Procedures

the Kaplan-Meier estimator in Uno’s Concordance Statistic

leesw0212 — Sun, 23 Aug 2020 20:13:05 GMT

Based on SAS User's Guide, it uses inverse probability weighting of the Kaplan-Meier estimator of the censoring distribution at the time point just before X_i which is G(X_i-)^(-2).

However, based on Uno's paper "On the C-Statistics for Evaluating Overall Adequacy of Risk Prediction Procedures with Censored Survival Data", it used the exact time point for the Kaplan-Meier, G(X_i)^(-2). Depending on which time point I use, it would give a slightly different value of the C-index.

I am not sure why SAS used the time point just before X_i for the Kaplan-Meier estimator which is G(X_i-)^(-2) because the paper used the exact time point X_i, which is G(X_i)^(-2), for the inverse probability weighting of the Kaplan-Meier estimator.

Should I use the exact time point or the time point just before X_i?

the Kaplan-Meier estimate from Uno’s Concordance Statistic

leesw0212 — Sun, 23 Aug 2020 05:50:00 GMT

Based on SAS User's Guide, it uses inverse probability weighting of the Kaplan-Meier estimator of the censoring distribution at the time point just before X_i.

However, based on Uno's paper "On the C-Statistics for Evaluating Overall Adequacy of Risk Prediction Procedures with Censored Survival Data", it used the exact time point for the Kaplan-Meier. Depending on which time point I use, it would give a slightly different value of the C-index.

Should I use the exact time point or the time point just before X_i?

Re: the Kaplan-Meier estimate from Uno’s Concordance Statistic

Rick_SAS — Sun, 23 Aug 2020 09:39:41 GMT

I haven't read the paper, but I can interpret the formula that you posted. If tau is the time of interest, the formula says to use the time points that strictly precede tau. Ths indicator variable I(X_i < tau) is zero when you use data equal to or greater than tau.

Re: the Kaplan-Meier estimate from Uno’s Concordance Statistic

leesw0212 — Sun, 23 Aug 2020 20:03:15 GMT

Thank you so much for your reply!

I understood that Tau is the upper limit of the time interval.

However, the question I have is why SAS used the time point just before X_i for the Kaplan-Meier estimator which is G(X_i-)^(-2). The paper used the exact time point X_i, which is G(X_i)^(-2), for the inverse probability weighting of the Kaplan-Meier estimator.

Re: the Kaplan-Meier estimate from Uno’s Concordance Statistic

SteveDenham — Mon, 24 Aug 2020 12:49:27 GMT

I think the most probable reason is that if you specified the exact time, the KM estimator would include any values observed up to, but not including the next time point. KM estimators are based on "open ended" intervals at the upper end, so I suspect the paper you are citing either used a 'closed end' cutoff (unlikely), or indexed the interval by the endpoint, rather than the beginning point. That is probably OK, unless you have just a single interval,

SteveDenham

Re: the Kaplan-Meier estimate from Uno’s Concordance Statistic

leesw0212 — Mon, 24 Aug 2020 13:08:34 GMT

Thank you so much for your reply!

That's very helpful 😄