https://communities.sas.com/t5/Statistical-Procedures/Power-for-sequential-design-with-non-inferiority-outcome/m-p/636220#M30488 <P>Hi,</P><P>&nbsp;</P><P>Is it possible to use PROC SEQDESIGN to calculate the required power/sample size for a sequential design where the primary outcome is tested under non-inferiority?</P><P>&nbsp;</P><P>For example, if the event is expected in 30% of the control &amp; the non-inferiority margin is 5%. How would I program a sequential design over 3 stages?</P><P>&nbsp;</P><P>Best wishes,</P><P>Bryony</P> Tue, 31 Mar 2020 13:14:43 GMT bryony1 2020-03-31T13:14:43Z https://communities.sas.com/t5/Statistical-Procedures/Power-for-sequential-design-with-non-inferiority-outcome/m-p/636220#M30488 <P>Hi,</P><P>&nbsp;</P><P>Is it possible to use PROC SEQDESIGN to calculate the required power/sample size for a sequential design where the primary outcome is tested under non-inferiority?</P><P>&nbsp;</P><P>For example, if the event is expected in 30% of the control &amp; the non-inferiority margin is 5%. How would I program a sequential design over 3 stages?</P><P>&nbsp;</P><P>Best wishes,</P><P>Bryony</P> Tue, 31 Mar 2020 13:14:43 GMT https://communities.sas.com/t5/Statistical-Procedures/Power-for-sequential-design-with-non-inferiority-outcome/m-p/636220#M30488 bryony1 2020-03-31T13:14:43Z https://communities.sas.com/t5/Statistical-Procedures/Power-for-sequential-design-with-non-inferiority-outcome/m-p/636677#M30489 <P>Moved to procedures forum where the chances of a reply are higher.</P> <P>&nbsp;</P> Wed, 01 Apr 2020 21:15:05 GMT https://communities.sas.com/t5/Statistical-Procedures/Power-for-sequential-design-with-non-inferiority-outcome/m-p/636677#M30489 ChrisNZ 2020-04-01T21:15:05Z