topic Lethal concentration (LC50) calculation in Statistical Procedures

Lethal concentration (LC50) calculation

Madiha1 — Sun, 30 Apr 2017 06:43:01 GMT

guys i m just stuck with lethal concentration (LC50) calculation.

I used two drugs of different concentrations as one dose in my experiment.i.e one is 250ug/L and other is 100mg/L both make one dose. how i write it and find LC50. problem is like

1. 250/100

2. 300/50

as units are different what should i do????

please guide me as soon as possible....

waiting for your reply...

i am using SAS University Edition

Lethal concentration (LC50) calculation

Madiha1 — Sat, 29 Apr 2017 16:08:48 GMT

guys i m just stuck with lethal concentration (LC50) calculation.

I used two drugs of different concentrations as one dose in my experiment.i.e one is 250ug/L and other is 100mg/L both make one dose. how i write it and find LC50. problem is like

1. 250/100

2. 300/50

as units are different what should i do????

please guide me as soon as possible....

waiting for your reply...

i am using SAS University Edition

Re: Lethal concentration (LC50) calculation

art297 — Sat, 29 Apr 2017 16:20:29 GMT

Can you be more specific? It would help if you provide data steps that show an example of what you have and, based on that example, what you want and what decision rules were needed to make the calculations/determinations.

Art, CEO, AnalystFinder.com

Re: SAS query

Rick_SAS — Sat, 29 Apr 2017 16:56:34 GMT

For one parameter, the lethal dose (50%) is the concentration for which the predicted probability is 0.5. So if you have two parameters, the lethal does would be a curve in parameter space for which the predicted probability is 0.5. You can use the EFFECTPLOT statement in PROC LOGISTIC or PROC PLM to create a contour plot that shows the 0.5 probability contour. For examples, see "Use the EFFECTPLOT statement to visualize regression models in SAS."

Re: Lethal concentration (LC50) calculation

Patrick — Sun, 30 Apr 2017 00:47:37 GMT

@Madiha1

To just answer the one specific question "as units are different what should i do????"

Convert your data to a common unit. 1mg = 1000ug

Re: Lethal concentration (LC50) calculation

Madiha1 — Sun, 30 Apr 2017 13:48:09 GMT

i am thinking too of converting them in unit. but problem is still how i write to doses at once to get LC

Re: Lethal concentration (LC50) calculation

Madiha1 — Sun, 30 Apr 2017 13:56:33 GMT

After conversion in one unit how to add dose concentration.

Re: Lethal concentration (LC50) calculation

Madiha1 — Tue, 02 May 2017 13:42:03 GMT

Normally for Calculation of LC50 calculation firstly according to method we have to add dose 
concentration,total number of animals and then number of mortality like the example below.
Here 2,4,6.. represents dose concentration. 

data A;
input dose n response;
cards;
2 50 10
4 50 25
6 50 35
8 50 40
10 50 45
;
proc probit log 10;
var dose n response;
run;



As i mentioned previously i am using two different concentrations as one dose.
how I write them.problm is I have my dose concentration in this form
220/50
300/100
400/150
when i put this this doesnt work.(both are different drugs which are taken as one dose concentration)
please reply me as soon as possible