topic Re: PROC Mixed newbie HELP! in SAS Procedures

PROC Mixed newbie HELP!

spatsassy — Fri, 22 Sep 2023 20:35:06 GMT

I am just starting out with PROC MIXED and unable to find help at my university, so hoping someone here can help!

I am setting up a model where my outcome (weight) is measured 3 times (baseline, 12m, 18m) there is so much variability with the time weight was actually measured (baseline-68months) that I am using a continuous "time since intervention" variable.

1. Do I need to center my time variable? why?

2. Is there a general rule of thumb on when to use random slope v random intercept v both random slope and intercept? When I run it with random intercept + slope the model shows no interaction between gender*time, while the random intercept only model does—any thoughts on why this might be?

My base model is:

Weight= time since intervention

and my model w covariates

weight= time since intervention +gender + age

I was going to include a time*time var since we believe people lose more weight earlier in the study- does this make sense?

When I DON’T center time this time*time var is significant vs not signif. when I do center time- any idea what this means?

i want to test time*gender to see if the rate of weight loss differs by gender and will add that in the next model. - does this make sense? does the time variable in this case need to be time*time*gender?

Any help or thoughts in general re mixed models is appreciated.

Re: PROC Mixed newbie HELP!

ballardw — Fri, 22 Sep 2023 21:01:05 GMT

Example of the raw data. Best as data step code pasted into a text box opened on the forum with the </> icon above the message window. Only need variables used in the model if that reduces the burden.

Example of what "centering" means to you or as applied to the raw data.

The entire Proc code.

Re: PROC Mixed newbie HELP!

spatsassy — Fri, 22 Sep 2023 21:31:00 GMT

Here is an example of the data (there are more ppts, this is just the first 25 rows)

Time= time in months from intervention.

When I speak of centering, I would grand mean center the variable as follows (subtract the mean of TIME from TIME for each row):

Time_Cent= TIME- Time_MEAN;:

</>

ID	WEIGHT	AGE	GENDER	TIME
25003	122.041	52	2	0
25003	122.002	52	2	5
25003	121.883	52	2	12
25001	121.762	56	3	0
25001	121.729	56	3	8
25001	121.691	56	3	12
25004	122.122	42	2	0
25004	122.051	42	2	7
25004	122.023	42	2	13
25009	121.79	66	1	0
25009	121.763	66	1	7
25009	.	66	1	.
25015	121.904	40	2	0
25015	.	40	2	.
25015	121.777	40	2	56
25026	121.909	56	2	0
25026	121.869	56	2	6
25026	121.843	56	2	12
25027	.	36	2	0
25027	.	36	2	.
25027	.	36	2	.
25048	121.619	48	2	0
25048	121.573	48	2	6
25048	121.568	48	2	12
25059	.	57	1	0

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