https://communities.sas.com/t5/SAS-Procedures/Repeated-Measures/m-p/26063#M5948 Hello. I want to see the relationship between an outcome variable dose measured six time on every subject.<BR /> interval time are unequally spaced: every subject has differente time points... example: subject n°1 has the second visit after 3 days and the third after 6 days and subject n°2 has the second visit after 8 days and the third after 2 ecc...<BR /> the dataset is like this<BR /> ID genotype_CYP2C9 eta sex date_1 dose_1 date_2 dose_2... date_6 dose_6<BR /> 1 N/N 64 M 28/02/08 34 31/03/08 24 25/09/09 13<BR /> 2 N/2 78 F 13/08/08 23 21/09/08 12 26/12/09 12<BR /> 3 N/3 65 F ecc<BR /> 4 N/N 68 M ecc<BR /> ...<BR /> what model i have to use?<BR /> proc mixed? proc genmod?<BR /> Iwant to see if dose changes over time and if there is a relation between genotype CYP2C9 and the dose of medicine.<BR /> thank you Mon, 01 Nov 2010 16:36:13 GMT deleted_user 2010-11-01T16:36:13Z https://communities.sas.com/t5/SAS-Procedures/Repeated-Measures/m-p/26063#M5948 Hello. I want to see the relationship between an outcome variable dose measured six time on every subject.<BR /> interval time are unequally spaced: every subject has differente time points... example: subject n°1 has the second visit after 3 days and the third after 6 days and subject n°2 has the second visit after 8 days and the third after 2 ecc...<BR /> the dataset is like this<BR /> ID genotype_CYP2C9 eta sex date_1 dose_1 date_2 dose_2... date_6 dose_6<BR /> 1 N/N 64 M 28/02/08 34 31/03/08 24 25/09/09 13<BR /> 2 N/2 78 F 13/08/08 23 21/09/08 12 26/12/09 12<BR /> 3 N/3 65 F ecc<BR /> 4 N/N 68 M ecc<BR /> ...<BR /> what model i have to use?<BR /> proc mixed? proc genmod?<BR /> Iwant to see if dose changes over time and if there is a relation between genotype CYP2C9 and the dose of medicine.<BR /> thank you Mon, 01 Nov 2010 16:36:13 GMT https://communities.sas.com/t5/SAS-Procedures/Repeated-Measures/m-p/26063#M5948 deleted_user 2010-11-01T16:36:13Z https://communities.sas.com/t5/SAS-Procedures/Repeated-Measures/m-p/26064#M5949 Hello, <BR /> <BR /> What distribution is the outcome variable? If it's normal then you can use Proc Mixed.<BR /> <BR /> Many thanks,<BR /> <BR /> Kriss Wed, 03 Nov 2010 14:23:28 GMT https://communities.sas.com/t5/SAS-Procedures/Repeated-Measures/m-p/26064#M5949 Risks 2010-11-03T14:23:28Z