How do i write a model statement for drug release kinetics

FestusAdejoro — Sun, 29 May 2016 18:16:08 GMT

I want to write a SAS syntax and run an analysis to evaluate the release of drug in an in vitro system across time periods.

I intend to use the First order and HIguchi model equations to get values of release constant.

The equations are

First Order: C = Coe(-kt)

Higuchi model : Mt / M∞ = Ktn (n is a superscript).

I would be grateful for any help.

Here is the syntax i was trying to develop:

DATA RELEASE;
Input TIME IVR SPECIES$;
Cards;
0.5 25.23453368 RCT

1 42.27780807 RCT

2 57.41862589 RCT

4 66.45725747 RCT

8 73.90717437 RCT

12 76.55205776 RCT

24 80.6309246 RCT

0.5 26.7912474 GCT

1 32.34728724 GCT

2 43.19154218 GCT

4 58.16394836 GCT

8 66.98968011 GCT

12 71.2555386 GCT

24 74.88005282 GCT

;

PROC SORT DATA = WORK.RELEASE;
BY SPECIES;
RUN;
PROC PLOT DATA = WORK.RELEASE;
BY SPECIES;
RUN;

Re: How do i write a model statement for drug release kinetics

PGStats — Sun, 29 May 2016 21:00:02 GMT

Use proc NLIN to fit your equations.

It is not clear what is the relationship between IVR, Mt and C.