Glimmix Repeated Measure Error

athomp06 — Tue, 08 Mar 2016 17:56:57 GMT

Can anyone tell me what the following error means?

WARNING: The R matrix depends on observation order within subjects. Omitting observations from
the analysis because of missing values can affect this matrix. Consider using a
classification effect in the RANDOM _RESIDUAL_ statement to determine ordering in the R
matrix.

I am attempting to run repeated measures on some data. The design was 20 animals blocked into light and heavy bodyweights, then assigned to 1 of 2 treatments withing each block. The animals had biopsies at 5 time points and gene expression was measured on 8 genes at each point. Attached is the SAS input as well as the output. I am not sure my denominator DF are correct and this may be associated with the error? Any help would be greatly appreciated.

Re: Glimmix Repeated Measure Error

cici0017 — Tue, 29 Mar 2016 18:24:20 GMT

When you have missing observations on the RANDOM _RESIDUAL_ statement in GLIMMIX then the procedure generates the warning message. Considering change the RANDOM _RESIDUAL_ to -

Proc glimmix data = JessicaPCR;

Class ID TRT BLOCK DAY;

Model AMPK = TRT|DAY/ddfm = KR;

random intercept / subject=BLOCK;

random intercept / subject=ID*TRT;

random day /subject = ID*TRT type=arh(1) residual;

LSMEANS TRT|DAY/ pdiff lines;

nloptions tech=nrridg;

Run;

The above RANDOM statement should make note go away.

topic Re: Glimmix Repeated Measure Error in SAS Procedures

Glimmix Repeated Measure Error

Re: Glimmix Repeated Measure Error