topic Re: Statistical Outlier Detection in SAS Health and Life Sciences

Statistical Outlier Detection

anil — Thu, 17 May 2007 05:57:45 GMT

Hi,
Pl help me in detecting outlier/inconsistent value of AUC & CMAX in BE study with 14 subjects

Re: Statistical Outlier Detection

deleted_user — Thu, 16 Aug 2007 09:13:04 GMT

You can use Lund's test which is approved by the USFDA for the outlier detection.
You can refer bolton's book for the same the sas code is also given there.

Re: Statistical Outlier Detection

anil — Tue, 28 Aug 2007 11:03:11 GMT

Thanks for the reference.

Is it necessary to apply statistical test to detect outliers in BA/BE studies for submission to USFDA?

I have found very few statisticians applying the test for 'outliers' (even if CV >30%)., some times they delete the volunteer from statistical analysis.

Experts pl offer help to resolve this issue.

Thanks

Anil