https://communities.sas.com/t5/SAS-Health-and-Life-Sciences/Prove-of-efficacy-in-one-patient/m-p/50859#M1407 see response under clinical trials. Tue, 07 Oct 2008 23:33:51 GMT Doc_Duke 2008-10-07T23:33:51Z https://communities.sas.com/t5/SAS-Health-and-Life-Sciences/Prove-of-efficacy-in-one-patient/m-p/50858#M1406 I have a question regarding the validity of a statistical test. If we take N randomly sample from a laboratory sample of the same patient and we obtain N values of the same parameter before the treatment and then we repeat the same thing some time later, after the treatment, is it correct to perform an unpaired test between the N values before treatment and N values after the treatment, in one patient? Is this a valid way to prove efficacy, or the repeated measure of a parameter in one patient is rather a reliability measurement?<BR /> <BR /> Thank you for your help. Wed, 01 Oct 2008 07:52:13 GMT https://communities.sas.com/t5/SAS-Health-and-Life-Sciences/Prove-of-efficacy-in-one-patient/m-p/50858#M1406 deleted_user 2008-10-01T07:52:13Z https://communities.sas.com/t5/SAS-Health-and-Life-Sciences/Prove-of-efficacy-in-one-patient/m-p/50859#M1407 see response under clinical trials. Tue, 07 Oct 2008 23:33:51 GMT https://communities.sas.com/t5/SAS-Health-and-Life-Sciences/Prove-of-efficacy-in-one-patient/m-p/50859#M1407 Doc_Duke 2008-10-07T23:33:51Z