Repeated measure ANOVA using PROC MIXED

deleted_user — Thu, 18 Sep 2008 02:08:18 GMT

My dataset has 16 subjects, each subject was exposed to 3 treatments, each treatment was repeated 4 times. So there is a correlation b/w the 4 times within a treatment, and another correlation factor b/w the 3 treatments within a subjects. The data looks like
ID Treatment Time
1 1 1
1 1 2
... ... ...
1 1 4
1 2 1
... ... ...
1 2 4
... ... ...
1 3 4
So the correlation matrix for subject 1 should be a 12*12 matrix, formed by 3*3=9 block matrices, and each matrix is a 4*4. The 3 diagonal 4*4 matrices should be the same. The off-diagonal 4*4 matrices don't need to be the same.
There are 2 difference correlation factors within a subject. My question is how to specify such a correlation matrix. Hopefully the correlation matrix should look like something like this
1 .5 .5 .5 .3 .3 .3 .3 .1 .1 .1 .1
.5 1 .5 .5 .3 .3 .3 .3 .1 .1 .1 .1
.5 .5 1 .5 .3 .3 .3 .3 .1 .1 .1 .1
.5 .5 .5 1 .3 .3 .3 .3 .1 .1 .1 .1
.3 .3 .3 .3 1 .5 .5 .5 .2 .2 .2 .2
.3 .3 .3 .3 .5 1 .5 .5 .2 .2 .2 .2
.3 .3 .3 .3 .5 .5 1 .5 .2 .2 .2 .2
.3 .3 .3 .3 .5 .5 .5 1 .2 .2 .2 .2
.1 .1 .1 .1 .2 .2 .2 .2 1 .5 .5 .5
.1 .1 .1 .1 .2 .2 .2 .2 .5 1 .5 .5
.1 .1 .1 .1 .2 .2 .2 .2 .5 .5 1 .5
.1 .1 .1 .1 .2 .2 .2 .2 .5 .5 .5 1

Re: Repeated measure ANOVA using PROC MIXED

1162 — Fri, 26 Sep 2008 17:27:21 GMT

In the REPEATED statement, there is an option called TYPE= that allows you to specify the covariance matrix. Try compound symmetry (CS) or autoregressive 1 (AR(1)). Autoregressive may suit you better since the correlation between two timepoints could be considered higher if the timepoints are closer together.

topic Re: Repeated measure ANOVA using PROC MIXED in SAS Health and Life Sciences

Repeated measure ANOVA using PROC MIXED

Re: Repeated measure ANOVA using PROC MIXED