How do I identify the index date based on line of therapy definitions?

jsyang56 — Mon, 07 Mar 2022 21:29:05 GMT

Hi, I'm very new to SAS and it would be great if someone can suggest some solutions because I just can't think of any.

Background: I'm using the IBM MarketScan data for my project and I need to identify index dates based on people's exposure to different drug classes. So far, I have cut my data down to people who have claims for receiving all drug classes of interest during the study period.

Problem: Now, I need some help with the following questions,

1) How do you create an algorithm or macros for a line of therapy (LOT) and apply the algorithm to each patient?

LOT Definitions

In general, a LOT consists of ≥ 1 complete cycle of one of the following,
- Single drug or
- A regimen that consists of a combination of different drugs

If one of the following conditions are met, it will be considered as an advancement in LOT
- All drugs of an existing regimen are discontinued, and a new regimen of different combinations of drugs is initiated
- Unplanned addition or substitution of a new drug to an existing regimen
- If the previously discontinued regimen is restarted later, the restarted regimen will be counted as a new LOT if
  - There is evidence of ≥ 1 other regimen administered in between the discontinued period
  - The regimen is modified through the addition of ≥1 drug

The following conditions do not meet the criteria for the advancement of LOT definition and will be considered as a single LOT,
- If a LOT is interrupted or discontinued for any reason and the same LOT is restarted <60 days after without any evidence of receiving other intervening LOT in between the gap

2) Once the LOT definition algorithms have been applied for each patient, I will need to identify the index date for each patient. The index date is defined as the first date of receiving a new LOT after completing a line of therapy with all three drug classes.

For example,
- Patient A completed the first LOT containing drug class A + B,
- Then advanced to the second LOT containing drug class C based on the definitions above,
- Then advanced to the third LOT containing drug class A + C
  - The first date of starting this LOT will be considered the index date

An example of my current dataset looks like this

ID	Date of service	Drug class received
1	01/13/2015	A
1	01/13/2015	B
1	01/21/2015	A
1	01/21/2015	B
1	02/05/2015	A
1	02/05/2015	B
1	04/01/2015	C
1	04/15/2015	C
1	04/27/2015	C
1	05/16/2015	A
1	05/16/2015	B

Based on the table above, the index date would be 05/16/2015. Then, I would like my new table to contain the same information, but contain claims after the index date.

If anyone can provide me with some ideas on how to get started, that would be greatly appreciated. Please let me know if you need more information from me.

Re: How do I identify the index date based on line of therapy definitions?

SASJedi — Tue, 08 Mar 2022 20:06:30 GMT

Using your current dataset as a base, please provide an example of what the desired dataset would look like.

Re: How do I identify the index date based on line of therapy definitions?

jsyang56 — Tue, 08 Mar 2022 20:24:38 GMT

Hello,

Thank you for your reply

I actually posted the same question in a different format for clarity. So, could you please help me figure out the answer to this question?

Link to the post:

https://communities.sas.com/t5/SAS-Programming/How-to-identify-observed-claims-within-a-period-of-time/m-p/800923

topic How do I identify the index date based on line of therapy definitions? in SAS Programming

How do I identify the index date based on line of therapy definitions?

Re: How do I identify the index date based on line of therapy definitions?

Re: How do I identify the index date based on line of therapy definitions?