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    <title>topic Re: HIV-1 polymorphism control elements as assay in gene residue in SAS Programming</title>
    <link>https://communities.sas.com/t5/SAS-Programming/HIV-1-polymorphism-control-elements-as-assay-in-gene-residue/m-p/214900#M307520</link>
    <description>&lt;HTML&gt;&lt;HEAD&gt;&lt;/HEAD&gt;&lt;BODY&gt;&lt;P&gt;Please provide a brief summary of what you are actually attempting to do, what your current data looks like and what you may be expecting for an output.&lt;/P&gt;&lt;P&gt;&lt;/P&gt;&lt;P&gt;I'm not going to attempt to read a 900K document to guess at the question or conditions.&lt;/P&gt;&lt;/BODY&gt;&lt;/HTML&gt;</description>
    <pubDate>Thu, 14 May 2015 19:49:39 GMT</pubDate>
    <dc:creator>ballardw</dc:creator>
    <dc:date>2015-05-14T19:49:39Z</dc:date>
    <item>
      <title>HIV-1 polymorphism control elements as assay in gene residue</title>
      <link>https://communities.sas.com/t5/SAS-Programming/HIV-1-polymorphism-control-elements-as-assay-in-gene-residue/m-p/214899#M307519</link>
      <description>&lt;HTML&gt;&lt;HEAD&gt;&lt;/HEAD&gt;&lt;BODY&gt;&lt;P&gt;Background:&lt;/P&gt;&lt;P&gt;HIV-1 impacts 3.2 million children, 35 million active cases,with 2013 estimates.&lt;/P&gt;&lt;P&gt;&lt;/P&gt;&lt;P&gt;In assay of the pathogen, it is possible to mine precursor elements of species donation via use of repeat elements of gene.&amp;nbsp; This observation is possible, within HIV-1,&lt;/P&gt;&lt;P&gt;using P-117 mole weight markers in repeat, observed precursor as potential donor in the avian species.&lt;/P&gt;&lt;P&gt;&lt;/P&gt;&lt;P&gt;Having demonstrated the beta model, it would be very useful to design high thru-put search regards...or active statistical&amp;nbsp; data via repeat.&amp;nbsp; Because the polymorphism&lt;/P&gt;&lt;P&gt;elements as mutagenic forward are variable, this is a difficult task.&lt;/P&gt;&lt;P&gt;&lt;/P&gt;&lt;P&gt;An example:&lt;/P&gt;&lt;P&gt;&lt;SPAN style="text-decoration: underline;"&gt;PPPPAI&lt;/SPAN&gt;&lt;/P&gt;&lt;P&gt;&lt;SPAN style="text-decoration: underline;"&gt;driven by the following data.&amp;nbsp;&amp;nbsp; Note the position value, mixed HIV complement:&lt;/SPAN&gt;&lt;/P&gt;&lt;P&gt;&lt;SPAN style="text-decoration: underline;"&gt;PPPPA&lt;/SPAN&gt;&lt;/P&gt;&lt;P&gt;&lt;/P&gt;&lt;P&gt;&lt;/P&gt;&lt;P&gt;&lt;SPAN style="text-decoration: underline;"&gt;The output of this assay, becomes a library of polymorphism control element via pathogen to host.&lt;/SPAN&gt;&lt;/P&gt;&lt;P&gt;&lt;/P&gt;&lt;P&gt;&lt;SPAN style="text-decoration: underline;"&gt;Why this is valuable, is also seen in MDR mutation, in non viral species.&lt;/SPAN&gt;&lt;/P&gt;&lt;P&gt;&lt;/P&gt;&lt;P&gt;&lt;SPAN style="text-decoration: underline;"&gt;You see, the problem of additive post polymorphism, gene residue, is a solution not easily solved with insertion forward sequence variant to search.&lt;/SPAN&gt;&lt;/P&gt;&lt;P&gt;&lt;SPAN style="text-decoration: underline;"&gt;The pathogenesis has impact to host via additive, larger residue set, post variable identity.&lt;/SPAN&gt;&lt;/P&gt;&lt;P&gt;&lt;/P&gt;&lt;P&gt;&lt;SPAN style="text-decoration: underline;"&gt;&lt;BR /&gt;&lt;/SPAN&gt; &lt;/P&gt;&lt;P&gt;&lt;A href="http://www.ncbi.nlm.nih.gov/protein/543378711?report=genbank&amp;amp;log$=protalign&amp;amp;blast_rank=0&amp;amp;RID=0"&gt;&lt;SPAN style="color: #0000ff; text-decoration: underline;"&gt;XP_005532556&lt;/SPAN&gt;&lt;/A&gt;&lt;SPAN style="text-decoration: underline;"&gt; 1 &lt;SPAN style="color: #ff00ff;"&gt;M&lt;/SPAN&gt;&lt;SPAN style="color: #0000ff;"&gt;SISGT&lt;/SPAN&gt;&lt;SPAN style="color: #ff00ff;"&gt;L&lt;/SPAN&gt;&lt;SPAN style="color: #0000ff;"&gt;SNYYVDS&lt;/SPAN&gt;&lt;SPAN style="color: #ff00ff;"&gt;I&lt;/SPAN&gt;&lt;SPAN style="color: #0000ff;"&gt;ISHESEDSPSSKFPPGQFSSR&lt;/SPAN&gt;&lt;SPAN style="color: #ff00ff;"&gt;Q&lt;/SPAN&gt;&lt;SPAN style="color: #0000ff;"&gt;SEHLEFPS&lt;/SPAN&gt;&lt;SPAN style="color: #ff00ff;"&gt;C&lt;/SPAN&gt;&lt;SPAN style="color: #0000ff;"&gt;SFQP&lt;/SPAN&gt;&lt;SPAN style="color: #ff00ff;"&gt;K&lt;/SPAN&gt;&lt;SPAN style="color: #0000ff;"&gt;PAVF&lt;/SPAN&gt;&lt;/SPAN&gt;&lt;/P&gt;&lt;P&gt;&lt;/P&gt;&lt;P&gt;&lt;SPAN style="text-decoration: underline;"&gt;passerine donor sequence data , avian to HIV -1 beta model with P-117, observation.&lt;/SPAN&gt;&lt;/P&gt;&lt;P&gt;&lt;/P&gt;&lt;P&gt;&lt;SPAN style="text-decoration: underline;"&gt;DAPPPAPAADGV&lt;/SPAN&gt;&lt;/P&gt;&lt;P&gt;&lt;/P&gt;&lt;P&gt;&lt;/P&gt;&lt;P&gt;&lt;SPAN style="text-decoration: underline;"&gt;I hope at least, to demonstrate the interesting problem of SNP solve.&lt;/SPAN&gt;&lt;/P&gt;&lt;P&gt;&lt;SPAN style="text-decoration: underline;"&gt;SNP, as conserved, cannot proceed in single identity, as it must be pair wise or larger set,&lt;/SPAN&gt;&lt;/P&gt;&lt;P&gt;&lt;SPAN style="text-decoration: underline;"&gt;to satisfy the underlying rules of reaction.&lt;/SPAN&gt;&lt;/P&gt;&lt;P&gt;&lt;/P&gt;&lt;P&gt;&lt;SPAN style="text-decoration: underline;"&gt;McGary&lt;/SPAN&gt;&lt;/P&gt;&lt;P&gt;&lt;SPAN style="text-decoration: underline;"&gt;&lt;BR /&gt;&lt;BR /&gt;&lt;BR /&gt;&lt;BR /&gt;&lt;BR /&gt;&lt;BR /&gt;&lt;BR /&gt;&lt;BR /&gt;&lt;BR /&gt;&lt;BR /&gt;&lt;BR /&gt;&lt;BR /&gt;&lt;/SPAN&gt;&lt;/P&gt;&lt;/BODY&gt;&lt;/HTML&gt;</description>
      <pubDate>Thu, 14 May 2015 14:08:54 GMT</pubDate>
      <guid>https://communities.sas.com/t5/SAS-Programming/HIV-1-polymorphism-control-elements-as-assay-in-gene-residue/m-p/214899#M307519</guid>
      <dc:creator>mmcgary44</dc:creator>
      <dc:date>2015-05-14T14:08:54Z</dc:date>
    </item>
    <item>
      <title>Re: HIV-1 polymorphism control elements as assay in gene residue</title>
      <link>https://communities.sas.com/t5/SAS-Programming/HIV-1-polymorphism-control-elements-as-assay-in-gene-residue/m-p/214900#M307520</link>
      <description>&lt;HTML&gt;&lt;HEAD&gt;&lt;/HEAD&gt;&lt;BODY&gt;&lt;P&gt;Please provide a brief summary of what you are actually attempting to do, what your current data looks like and what you may be expecting for an output.&lt;/P&gt;&lt;P&gt;&lt;/P&gt;&lt;P&gt;I'm not going to attempt to read a 900K document to guess at the question or conditions.&lt;/P&gt;&lt;/BODY&gt;&lt;/HTML&gt;</description>
      <pubDate>Thu, 14 May 2015 19:49:39 GMT</pubDate>
      <guid>https://communities.sas.com/t5/SAS-Programming/HIV-1-polymorphism-control-elements-as-assay-in-gene-residue/m-p/214900#M307520</guid>
      <dc:creator>ballardw</dc:creator>
      <dc:date>2015-05-14T19:49:39Z</dc:date>
    </item>
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