topic Re: how to calculate differences from a baseline value in SAS Programming

how to calculate differences from a baseline value

chucs — Thu, 11 Jul 2013 15:28:32 GMT

Hi all,

I have a data set created with the following code:

data test;

input id $ dxday caetype $;

datalines;

01 1890 NONSP

01 2120 INFL

01 2128 INFL

01 2135 INFL

01 2137 NONSP

02 -775 INFL

02 -569 NONSP

03 3020 ARR

03 3026 NONSP

03 3027 NONSP

03 3175 INFL

;

run;

The 3 variables denote patient ID number, number of days the patient experienced a cardiac adverse event (CAE) relative to a certain vaccination, and type of CAE. I'm trying to calculate differences in the number of days from a baseline value for each patient, where the baseline value is the first occurrence of a CAE with type 'INFL'. So, for ID 01, the first INFL CAE occurs at the 2nd observation (dxday=2120); for ID 02, the first INFL CAE occurs at the 1st observation (dxday=-775); and for ID 03 the first INFL CAE occurs at the last observation (dxday=3175).

What I'd like to do is to create a difference variable (DIFF) that calculates time differences based on the correctly identified baseline time value for each patient. So, what I'd like to end up with is a data set that looks like this:

id	dxday	caetype	DIFF
01	1890	NONSP	-230
01	2120	INFL	0
01	2128	INFL	8
01	2135	INFL	15
01	2137	NONSP	17
02	-775	INFL	0
02	-569	NONSP	206
03	3020	ARR	-155
03	3026	NONSP	-149
03	3027	NONSP	-148
03	3175	INFL	0

Can anyone provide any insight on how to do this? Thanks so much!

chucsp

Re: how to calculate differences from a baseline value

Anotherdream — Thu, 11 Jul 2013 15:50:37 GMT

First get a dataset that keeps the first value of caetype per each ID, along with the dxday, then re-merge that dataset onto the original and find the difference. The following code will do the trick rather easily.

Note: You did not specify how to define the "First" value of each INFL per id, so I am going to assume the base order of the data (aka the variable _n_) is the correct variable to find the "first" value.

data test1;

set test;

ordervar=_N_;

if caetype='INFL';

run;

sort data=test1;

by id ordervar;

run;

data joinvalues(drop=ordervar caetype);

set test1;

by id ordervar;

if first.id=1 then output;

run;

proc sql;

create table answer as

select t1.*

,t1.dxday-jv.dxday as diff

from test t1

join joinvalues jv on jv.id=t1.id;

quit;

run;

Re: how to calculate differences from a baseline value

sam369 — Thu, 11 Jul 2013 18:11:01 GMT

Hi Chucs,

May be some one come up with better answer. here is the sample code where you can get the desired o/p

proc sql;

create table want as

select a.*,b.baseday,(dxday-baseday) as diff

from have as a left join(select id,dxday as baseday from have(where=(caetype eq 'INFL'))

group by id having dxday=min(dxday)) as b

on a.id=b.id

order by a.id,a.dxday;

quit;

Thanks

Sam

Re: how to calculate differences from a baseline value

Astounding — Thu, 11 Jul 2013 20:03:47 GMT

Chucs,

SQL is more of my weak spot, so I would go about it like this.

data want;

do until (last.id);

set have;

by id;

if baseline =. and caetype='INFL' then baseline = dxday;

end;

do until (last.id);

set have;

by id;

diff = dxday - baseline;

output;

end;

run;

The logic assumes that your data are already in order BY ID DXDAY. Optionally, you might want to drop BASELINE;

Good luck.

Re: how to calculate differences from a baseline value

chucs — Fri, 12 Jul 2013 15:30:41 GMT

Thanks to everyone for their response! I'll give them a try.