topic Re: Heterogeneity test on a difference in the HR(hazard ratio) for subgroups in SAS Programming

Heterogeneity test on a difference in the HR(hazard ratio) for subgroups

eugenecs — Sun, 31 Oct 2021 08:46:36 GMT

I would be grateful if someone could help me with the code to find an overall p-value for heterogeneity of association by age of onset.

Our primary hypothesis test was heterogeneity test on a difference in the HR(hazard ratio) for one subgroup (age<45 years), the HR for another subgroup (age 45-55 years) and the HR for the third subgroup (55-65 years) as an ordinal statistical trend. Specifically, we assessed whether the magnitude of the subgroup-specific associations had an increasing or decreasing ordinal trend according to age.

Re: Heterogeneity test on a difference in the HR(hazard ratio) for subgroups

sbxkoenk — Sun, 31 Oct 2021 13:18:04 GMT

Hello @eugenecs ,

Can you explain why the HAZARDRATIO Statement in PROC PHREG is not helping you out here?

For a CLASS variable, a hazard ratio compares the hazards of two levels of the variable.

Thanks,

Koen

Re: Heterogeneity test on a difference in the HR(hazard ratio) for subgroups

eugenecs — Sun, 31 Oct 2021 13:33:47 GMT

Thank you for your comments. Actually, I want to do a trend test to examine the trend in hazard ratio among the subgroup.

Re: Heterogeneity test on a difference in the HR(hazard ratio) for subgroups

sbxkoenk — Sun, 31 Oct 2021 13:51:40 GMT

Hello @eugenecs ,

Have a look to this .pdf from SAS Documentation :

SAS/STAT® 13.1 User’s Guide
The PHREG Procedure

https://support.sas.com/documentation/onlinedoc/stat/131/phreg.pdf

and search for :

' A Simple Test of Trend in the Hazard Ratio'.

On page 5915, you bump into such a test

which is searching for evidence of an increasing or decreasing trend over time in the hazard ratio

, but instead of << time >> you can use another factor.

Thanks,

Koen