Treatment day0 day3 day7 day14 day30 day90 day180 day360 day720 2 8.4 6.3 7.7 9.2 10.2 12.9 2 8.5 7.2 9.5 10.2 10.6 2 8 9.3 9.1 9.5 8.7 2 12.7 16.8 14.3 13.4 2 9.4 7.6 8.3 10.3 10.4 12.4 11.6 12.4 2 7 6.7 8.7 10.6 12 2 9.5 9 9.4 10.3 11.5 12.4 13.5 13.8 2 8.7 7.2 6.8 7.6 7.9 2 9.7 7.8 7.1 9.2 10.7 10.8 10.1 11.4 2 8.7 8 8.3 10.1 11.1 13.4 13 12.1 13.9 2 9.3 7.1 9 8.9 15 16.9 2 5.7 7.7 10.6 8.4 10.1 11.1 12.2 2 11.6 10.2 11.1 11.1 12.1 14.5 2 7.3 6.9 7.4 10.7 11.4 13.2 13.9 8.6 10.6 10.1 9.2 11.9 14.7 6.6 9 8.9 11.7 2 9.7 9.2 9.7 9.9 2 7.8 6.1 9.6 9.1 2 6.1 5.7 6.8 6.9 10.7 15.2 2 9.7 10.6 8.7 9.4 10.4 13.4 14.6 2 8.9 9.8 13.5 6.7 8.8 11.9 11.2 2 10.1 8.3 8.4 11.1 13.6 16.3 19.4 2 8.6 6.6 7.7 8.9 9.7 11.1 9.9 2 10.4 12.1 11.1 9.8 7.5 11.7 2 8.5 7.9 7.5 8.7 9.8 14.1 15.6 2 7.8 7.2 7.6 10.4 12.7 13.6 14.7 2 9.8 10 9.7 10.1 2 9.7 10.1 10.5 10.3 13.3 13.7 2 7.1 7.2 8.4 9.4 13.8 2 8.5 7.2 8.3 10 12.5 2 10.1 8.1 9.7 10.2 10.3 12.2 13.8 2 8 7.7 9.4 9.9 10.4 9.9 2 8.8 6.9 8.4 8.6 8.9 2 6.4 7.3 7.3 7.9 9.3 2 11.2 10.6 11.6 11.6 11.7 12.1 2 9.9 8.2 10.1 11 11.7 11.8 2 7.9 7.4 9.2 2 10.6 11.4 12.7 2 10.2 11.1 2 7.3 7.4 9.1 9.5 11.2 13.8 2 10.8 9.6 10.2 9.7 10.2 10.3 2 10.9 10.2 11.1 12 12.8 15 2 9.1 9.1 11.8 8.8 8.6 2 8.5 8.4 9.1 10.6 11.5 15.3 2 10.8 9.4 10.2 10.3 10.7 2 7.8 7 7.4 9.4 11.2 12.7 2 10.1 8.9 9.6 10.7 11.5 2 7.1 7.8 8.1 8.9 11 2 10.4 9.1 10.4 9.4 2 10.2 6.7 9.2 2 7.6 6.1 7.8 8.8 2 7.6 6.1 7.8 8.8 2 12.2 7.4 10.2 2 9.2 9.1 2 8.3 8.5 10 2 6.7 8.7 6.6 2 9.2 7.9 8.7 2 11.6