Treatment day0 day3 day7 day14 day30 day90 day180 day360 day720 1 7.7 8.9 9.3 10.2 13.4 12 13.9 1 8.4 8.6 9.6 9.4 11.9 13.7 14.3 1 10.5 11.9 12.7 13.3 12.9 10.3 1 7.4 7.4 7.1 8.8 11.1 11.4 1 7.8 7.2 8.6 9.2 10.3 1 6.9 6.1 7.7 9.3 11.1 1 12.2 11.8 12.5 12.5 13.4 1 7.8 9.9 4.5 9.9 13.7 1 6.8 6.3 7.5