Listing 16.3
Deaths through Week 24
Full Analysis Set 
No Death Reported

Notes: Full Analysis Set includes randomized, treated subjects with at least part of one dose of study treatment, as-treated.

Output: l-death    Snapshot Date: 31 August 2011
S:\TEST\PROD\LISTINGS\PGM\L-DEATH.sas

Calibri (Vietnamese);Times New Roman CE;Times New Roman Cyr;Times New Roman Greek;Times New Roman Tur;Times New Roman (Hebrew);Times New Roman (Arabic);Times New Roman Baltic;Times New Roman (Vietnamese);Listing 16.1
Demographic and Baseline Characteristics
Full Analysis Set

Treatment Arm

Subject Number

Randomization Factor

Age (years)

Gender

Race

Ethnicity

Height
(cm)

Weight
(kg)

BMI
(kg/
m2)

A 5mg | 101-008 | >=65 years/Asthma | 71 | Female | Native Hawaiian or Other Pacific Islander | Not Hispanic or Latino | 152 | 71.6 | 31.0
| 101-011 | >=65 years/Current Smoker | 73 | Male | White | Not Hispanic or Latino | 170.2 | 62.8 | 21.7
| 101-012 | >=65 years/Asthma | 70 | Female | Native Hawaiian or Other Pacific Islander | Not Hispanic or Latino | 154 | 67.6 | 28.5
| 101-015 | >=65 years/Asthma | 73 | Female | White | Not Hispanic or Latino | 158.3 | 56.3 | 22.5
| 101-020 | >=65 years/Current Smoker | 69 | Male | White | Not Hispanic or Latino | 180.3 | 63.4 | 19.5
| 101-022 | >=85 years | 87 | Male | White | Not Hispanic or Latino | 170.5 | 81.7 | 28.1
| 102-006 | >=65 years/T2DM | 68 | Male | White | Not Hispanic or Latino | 171 | 83.2 | 28.5
| 102-008 | >=65 years/T2DM | 75 | Male | White | Not Hispanic or Latino | 168 | 70.8 | 25.1
| 102-009 | >=65 years/CHF | 81 | Male | White | Not Hispanic or Latino | 164 | 73.8 | 27.4
| 102-012 | >=65 years/T2DM | 71 | Male | White | Not Hispanic or Latino | 169 | 84.4 | 29.6
| 102-019 | >=65 years/T2DM | 68 | Male | White | Not Hispanic or Latino | 184 | 113.7 | 33.6
| 103-003 | >=85 years | 86 | Female | Other: White (European + Maori) | Not Hispanic or Latino | 162.5 | 54.7 | 20.7
| 103-007 | >=65 years/Asthma | 70 | Female | White | Not Hispanic or Latino | 152 | 86.5 | 37.4
| 103-008 | >=65 years/Current Smoker | 70 | Female | White | Not Hispanic or Latino | 158 | 63.9 | 25.6
| 103-012 | >=65 years/Asthma | 76 | Female | White | Not Hispanic or Latino | 168 | 55.8 | 19.8
| 103-014 | >=65 years/T2DM | 68 | Male | White | Not Hispanic or Latino | 169.4 | 89.4 | 31.2
| 103-018 | >=85 years | 85 | Female | White | Not Hispanic or Latino | 164.5 | 49.6 | 18.3
| 103-019 | >=65 years/Asthma | 67 | Male | White | Not Hispanic or Latino | 178 | 76.1 | 24.0
| 104-007 | >=65 years/Chronic Bronchitis or COPD | 66 | Male | White | Not Hispanic or Latino | 179 | 106.9 | 33.4
| 104-014 | >=65 years/Chronic Bronchitis or COPD | 77 | Male | White | Not Hispanic or Latino | 163.5 | 69 | 25.8
| 104-018 | >=65 years/T2DM | 72 | Female | White | Not Hispanic or Latino | 161.5 | 61.9 | 23.7
| 104-019 | >=65 years/Asthma | 65 | Female | White | Not Hispanic or Latino | 167 | 63.4 | 22.7
| 105-003 | >=85 years | 90 | Male | White | Not Hispanic or Latino | 166 | 68.2 | 24.7
| 105-010 | >=65 years/T2DM | 68 | Male | White | Not Hispanic or Latino | 161 | 77.3 | 29.8

Notes: Full Analysis Set includes randomized, treated subjects with at least part of one dose of study treatment, as-treated.
Body Mass Index (BMI) is derived using the formula BMI = (weight/height^2).

Output: l-demo     Snapshot Date: 22 August 2022
S: \PROD\LISTINGS\PGM\L-DEMO.sas

Listing 16.1
Demographic and Baseline Characteristics
Full Analysis Set

Treatment Arm

Subject Number

Randomization Factor

Age (years)

Gender

Race

Ethnicity

Height
(cm)

Weight
(kg)

BMI
(kg/
m2)

A 5mg | 105-013 | >=65 years/Chronic Bronchitis or COPD | 71 | Male | White | Not Hispanic or Latino | 177.5 | 88.1 | 28.0
| 105-017 | >=65 years/T2DM | 69 | Male | White | Not Hispanic or Latino | 170.4 | 100 | 34.4
| 105-018 | >=65 years/Chronic Bronchitis or COPD | 70 | Female | White | Not Hispanic or Latino | 168 | 82 | 29.1
| 105-021 | >=65 years/Asthma | 84 | Female | White | Not Hispanic or Latino | 156 | 55 | 22.6
| 105-024 | >=65 years/Chronic Bronchitis or COPD | 79 | Male | White | Not Hispanic or Latino | 170 | 99.6 | 34.5
| 106-003 | >=65 years/Chronic Bronchitis or COPD | 73 | Female | White | Not Hispanic or Latino | 158.5 | 73.4 | 29.2
| 106-010 | >=85 years | 85 | Female | White | Not Hispanic or Latino | 157 | 77.6 | 31.5
| 106-012 | >=65 years/T2DM | 70 | Male | White | Not Hispanic or Latino | 164.3 | 101 | 37.4
| 107-002 | >=65 years/Current Smoker | 67 | Male | White | Not Hispanic or Latino | 177.3 | 92.6 | 29.5
| 107-004 | >=85 years | 92 | Female | White | Not Hispanic or Latino | 155.5 | 57 | 23.6
| 107-005 | >=65 years/T2DM | 69 | Female | White | Not Hispanic or Latino | 153.5 | 83.2 | 35.3
| 107-011 | >=65 years/Asthma | 72 | Male | White | Not Hispanic or Latino | 171.8 | 86.9 | 29.4
| 107-012 | >=65 years/Chronic Bronchitis or COPD | 65 | Male | White | Not Hispanic or Latino | 178.6 | 87 | 27.3
| 107-023 | >=85 years | 95 | Female | White | Not Hispanic or Latino | 158.2 | 70.9 | 28.3
| 107-024 | >=85 years | 91 | Male | White | Not Hispanic or Latino | 168.8 | 82.6 | 29.0
| 107-025 | >=65 years/Chronic Bronchitis or COPD | 72 | Male | White | Not Hispanic or Latino | 167 | 78.4 | 28.1
| 108-001 | >=65 years/Current Smoker | 65 | Female | White | Not Hispanic or Latino | 166.5 | 78.2 | 28.2
| 108-004 | >=65 years/T2DM | 67 | Male | White | Not Hispanic or Latino | 165 | 101.5 | 37.3
| 108-007 | >=65 years/Chronic Bronchitis or COPD | 67 | Male | White | Not Hispanic or Latino | 174.2 | 87.6 | 28.9
| 108-010 | >=65 years/T2DM | 74 | Female | White | Not Hispanic or Latino | 159.9 | 99.3 | 38.8
| 108-014 | >=65 years/Current Smoker | 66 | Female | White | Not Hispanic or Latino | 167 | 67.9 | 24.3
| 108-021 | >=85 years | 85 | Male | White | Not Hispanic or Latino | 161.2 | 71 | 27.3
| 108-022 | >=85 years | 87 | Female | White | Not Hispanic or Latino | 155.8 | 76 | 31.3

Notes: Full Analysis Set includes randomized, treated subjects with at least part of one dose of study treatment, as-treated.
Body Mass Index (BMI) is derived using the formula BMI = (weight/height^2).

Output: l-demo     Snapshot Date: 22 August 2022
S:\PROD\LISTINGS\PGM\L-DEMO.sas

Listing 16.1
Demographic and Baseline Characteristics
Full Analysis Set

Treatment Arm

Subject Number

Randomization Factor

Age (years)

Gender

Race

Ethnicity

Height
(cm)

Weight
(kg)

BMI
(kg/
m2)

A 5mg | 108-023 | >=85 years | 85 | Male | White | Not Hispanic or Latino | 159 | 59 | 23.3
| 108-026 | >=65 years/T2DM | 68 | Female | White | Not Hispanic or Latino | 170 | 98.2 | 34.0
| 108-029 | >=65 years/T2DM | 71 | Male | White | Not Hispanic or Latino | 172.5 | 109.9 | 36.9
| 108-030 | >=65 years/T2DM | 65 | Male | White | Not Hispanic or Latino | 170.5 | 94.6 | 32.5
| 109-001 | >=65 years/Chronic Bronchitis or COPD | 66 | Female | White | Not Hispanic or Latino | 163 | 109.4 | 41.2
| 109-004 | >=65 years/T2DM | 67 | Male | White | Not Hispanic or Latino | 164 | 82.7 | 30.7
| 109-005 | >=65 years/T2DM | 78 | Male | White | Not Hispanic or Latino | 180 | 90 | 27.8
| 109-007 | >=65 years/T2DM | 69 | Male | Asian | Not Hispanic or Latino | 154 | 60.8 | 25.6
| 109-008 | >=65 years/T2DM | 81 | Male | White | Not Hispanic or Latino | 181 | 89 | 27.2
| 109-011 | >=65 years/Asthma | 68 | Female | White | Not Hispanic or Latino | 162 | 63.2 | 24.1
| 109-012 | >=65 years/Asthma | 65 | Female | White | Not Hispanic or Latino | 155 | 68.2 | 28.4
| 109-017 | >=85 years | 88 | Female | Asian | Not Hispanic or Latino | 144 | 45.9 | 22.1
| 109-021 | >=65 years/Asthma | 69 | Female | White | Not Hispanic or Latino | 166.5 | 59.7 | 21.5
| 110-006 | >=65 years/T2DM | 71 | Female | White | Not Hispanic or Latino | 153 | 72.4 | 30.9
A 10mg QD | 101-005 | >=65 years/T2DM | 76 | Female | White | Not Hispanic or Latino | 161.1 | 82.5 | 31.8
| 101-007 | >=65 years/Asthma | 75 | Female | White | Not Hispanic or Latino | 168 | 91.2 | 32.3
| 101-010 | >=65 years/T2DM | 71 | Male | Native Hawaiian or Other Pacific Islander | Not Hispanic or Latino | 170.6 | 90 | 30.9
| 101-013 | >=65 years/Asthma | 73 | Female | White | Not Hispanic or Latino | 160 | 79 | 30.9
| 101-018 | >=65 years/Current Smoker | 71 | Male | White | Not Hispanic or Latino | 187.4 | 94.8 | 27.0
| 101-027 | >=85 years | 89 | Male | White | Not Hispanic or Latino | 172.5 | 66.9 | 22.5
| 101-029 | >=85 years | 88 | Female | White | Not Hispanic or Latino | 144.5 | 52.1 | 25.0
| 101-030 | >=85 years | 91 | Female | White | Not Hispanic or Latino | 164 | 67.8 | 25.2
| 101-031 | >=65 years/Current Smoker | 67 | Male | White | Not Hispanic or Latino | 175.5 | 116.3 | 37.8
| 102-001 | >=65 years/T2DM | 78 | Female | White | Not Hispanic or Latino | 154 | 104.4 | 44.0
| 102-003 | >=65 years/T2DM | 66 | Male | White | Not Hispanic or Latino | 173 | 105.9 | 35.4
| 102-013 | >=65 years/T2DM | 79 | Male | White | Not Hispanic or Latino | 172 | 77.8 | 26.3
| 102-014 | >=65 years/Asthma | 80 | Female | White | Not Hispanic or Latino | 151 | 79.4 | 34.8

Notes: Full Analysis Set includes randomized, treated subjects with at least part of one dose of study treatment, as-treated.
Body Mass Index (BMI) is derived using the formula BMI = (weight/height^2).

Output: l-demo     Snapshot Date: 22 August 2022
S:\PROD\LISTINGS\PGM\L-DEMO.sas

Listing 16.1
Demographic and Baseline Characteristics
Full Analysis Set

Treatment Arm

Subject Number

Randomization Factor

Age (years)

Gender

Race

Ethnicity

Height
(cm)

Weight
(kg)

BMI
(kg/
m2)

A 10mg QD | 102-017 | >=85 years | 88 | Female | White | Not Hispanic or Latino | 151 | 60.1 | 26.4
| 103-001 | >=65 years/T2DM | 83 | Female | Asian | Not Hispanic or Latino | 150 | 42.1 | 18.7
| 103-009 | >=65 years/Asthma | 69 | Female | White | Not Hispanic or Latino | 158 | 88.9 | 35.6
| 103-011 | >=65 years/Asthma | 72 | Male | White | Not Hispanic or Latino | 185 | 88.5 | 25.9
| 103-013 | >=65 years/T2DM | 84 | Male | White | Not Hispanic or Latino | 160 | 64.8 | 25.3
| 103-015 | >=85 years | 87 | Male | White | Not Hispanic or Latino | 167.6 | 99.1 | 35.3
| 103-016 | >=85 years | 90 | Male | White | Not Hispanic or Latino | 176 | 72.5 | 23.4
| 104-006 | >=65 years/Chronic Bronchitis or COPD | 76 | Male | White | Not Hispanic or Latino | 174 | 107.7 | 35.6
| 104-009 | >=85 years | 87 | Male | White | Not Hispanic or Latino | 167.5 | 72.3 | 25.8
| 104-016 | >=85 years | 86 | Male | White | Not Hispanic or Latino | 173 | 73.4 | 24.5
| 104-020 | >=65 years/T2DM | 81 | Female | Asian | Not Hispanic or Latino | 151.5 | 45.9 | 20.0
| 105-002 | >=65 years/T2DM | 73 | Female | White | Not Hispanic or Latino | 170 | 92 | 31.8
| 105-012 | >=65 years/Chronic Bronchitis or COPD | 67 | Male | White | Not Hispanic or Latino | 182 | 107.1 | 32.3
| 105-020 | >=65 years/T2DM | 67 | Male | White | Not Hispanic or Latino | 161.7 | 107.5 | 41.1
| 106-002 | >=65 years/Chronic Bronchitis or COPD | 69 | Male | White | Not Hispanic or Latino | 174 | 68.7 | 22.7
| 106-004 | >=65 years/Chronic Bronchitis or COPD | 69 | Female | White | Not Hispanic or Latino | 160.6 | 68 | 26.4
| 106-007 | >=85 years | 89 | Male | White | Not Hispanic or Latino | 168.7 | 81.7 | 28.7
| 106-008 | >=65 years/Asthma | 76 | Male | White | Not Hispanic or Latino | 174.5 | 68.5 | 22.5
| 106-011 | >=65 years/Asthma | 67 | Female | Native Hawaiian or Other Pacific Islander | Not Hispanic or Latino | 162 | 79.7 | 30.4
| 107-001 | >=65 years/Chronic Bronchitis or COPD | 74 | Female | White | Not Hispanic or Latino | 168 | 84.3 | 29.9
| 107-008 | >=65 years/Asthma | 69 | Male | White | Not Hispanic or Latino | 168.5 | 77.6 | 27.3
| 107-009 | >=65 years/Asthma | 78 | Female | White | Not Hispanic or Latino | 161.2 | 84.5 | 32.5
| 107-014 | >=65 years/Chronic Bronchitis or COPD | 77 | Female | White | Not Hispanic or Latino | 165.4 | 83.2 | 30.4

Notes: Full Analysis Set includes randomized, treated subjects with at least part of one dose of study treatment, as-treated.
Body Mass Index (BMI) is derived using the formula BMI = (weight/height^2).

Output: l-demo     Snapshot Date: 22 August 2022
S:\PROD\LISTINGS\PGM\L-DEMO.sas

Listing 16.1
Demographic and Baseline Characteristics
Full Analysis Set

Treatment Arm

Subject Number

Randomization Factor

Age (years)

Gender

Race

Ethnicity

Height
(cm)

Weight
(kg)

BMI
(kg/
m2)

A 10mg QD | 107-017 | >=65 years/T2DM | 75 | Male | White | Not Hispanic or Latino | 169.5 | 83.9 | 29.2
| 107-019 | >=65 years/Asthma | 69 | Female | White | Not Hispanic or Latino | 163.1 | 61.3 | 23.0
| 107-021 | >=85 years | 93 | Male | White | Not Hispanic or Latino | 169.4 | 79.9 | 27.8
| 108-002 | >=65 years/Current Smoker | 76 | Female | White | Not Hispanic or Latino | 161 | 60.6 | 23.4
| 108-003 | >=65 years/T2DM | 68 | Male | White | Not Hispanic or Latino | 170.5 | 99.3 | 34.2
| 108-009 | >=65 years/Current Smoker | 69 | Male | White | Not Hispanic or Latino | 172 | 79.8 | 27.0
| 108-015 | >=65 years/Asthma | 65 | Female | White | Not Hispanic or Latino | 171.8 | 111.9 | 37.9
| 108-016 | >=65 years/Current Smoker | 70 | Male | White | Not Hispanic or Latino | 158.2 | 69.5 | 27.8
| 108-017 | >=65 years/T2DM | 65 | Male | White | Not Hispanic or Latino | 168.9 | 88.3 | 31.0
| 108-018 | >=65 years/T2DM | 75 | Female | White | Not Hispanic or Latino | 152.5 | 91.8 | 39.5
| 108-019 | >=65 years/Current Smoker | 70 | Male | White | Not Hispanic or Latino | 191.2 | 91.3 | 25.0
| 108-020 | >=65 years/T2DM | 74 | Female | White | Not Hispanic or Latino | 161.8 | 80.8 | 30.9
| 108-024 | >=85 years | 89 | Female | White | Not Hispanic or Latino | 157.6 | 72.5 | 29.2
| 108-025 | >=65 years/T2DM | 67 | Female | White | Not Hispanic or Latino | 160 | 125.3 | 48.9
| 108-028 | >=65 years/T2DM | 79 | Female | White | Not Hispanic or Latino | 164.2 | 80.8 | 30.0
| 109-006 | >=65 years/T2DM | 77 | Male | White | Not Hispanic or Latino | 170.5 | 90.5 | 31.1
| 109-009 | >=65 years/T2DM | 76 | Male | White | Not Hispanic or Latino | 168.5 | 101 | 35.6
| 109-013 | >=65 years/Asthma | 78 | Male | White | Not Hispanic or Latino | 164 | 83 | 30.9
| 109-014 | >=65 years/Chronic Bronchitis or COPD | 82 | Male | White | Not Hispanic or Latino | 178 | 105.9 | 33.4
| 109-020 | >=85 years | 90 | Male | White | Not Hispanic or Latino | 157.2 | 76 | 30.8
| 110-002 | >=65 years/Chronic Bronchitis or COPD | 80 | Female | White | Not Hispanic or Latino | 154.2 | 77.5 | 32.6
| 110-003 | >=65 years/Asthma | 69 | Female | White | Not Hispanic or Latino | 160 | 62.5 | 24.4
Placebo | 101-001 | >=65 years/T2DM | 69 | Male | Native Hawaiian or Other Pacific Islander | Not Hispanic or Latino | 172 | 90.3 | 30.5
| 101-002 | >=65 years/T2DM | 65 | Female | White | Not Hispanic or Latino | 140.5 | 57.8 | 29.3
| 101-004 | >=65 years/Asthma | 72 | Male | White | Not Hispanic or Latino | 168 | 75.5 | 26.8
| 101-009 | >=65 years/Asthma | 69 | Female | White | Not Hispanic or Latino | 160.1 | 64.2 | 25.0

Notes: Full Analysis Set includes randomized, treated subjects with at least part of one dose of study treatment, as-treated.
Body Mass Index (BMI) is derived using the formula BMI = (weight/height^2).

Output: l-demo     Snapshot Date: 22 August 2022
S:\PROD\LISTINGS\PGM\L-DEMO.sas

Listing 16.1
Demographic and Baseline Characteristics
Full Analysis Set

Treatment Arm

Subject Number

Randomization Factor

Age (years)

Gender

Race

Ethnicity

Height
(cm)

Weight
(kg)

BMI
(kg/
m2)

Placebo | 101-016 | >=65 years/Asthma | 74 | Male | White | Not Hispanic or Latino | 180.1 | 85.9 | 26.5
| 101-019 | >=65 years/Asthma | 71 | Male | White | Not Hispanic or Latino | 172.3 | 66.8 | 22.5
| 101-021 | >=65 years/Current Smoker | 70 | Male | White | Not Hispanic or Latino | 167 | 92.1 | 33.0
| 101-024 | >=65 years/Current Smoker | 72 | Male | White | Not Hispanic or Latino | 178.6 | 81.3 | 25.5
| 101-026 | >=85 years | 87 | Male | White | Not Hispanic or Latino | 162.4 | 58.3 | 22.1
| 102-004 | >=65 years/T2DM | 69 | Female | White | Not Hispanic or Latino | 150.5 | 64.9 | 28.7
| 102-010 | >=65 years/T2DM | 70 | Female | White | Not Hispanic or Latino | 155 | 68 | 28.3
| 102-011 | >=65 years/T2DM | 72 | Male | White | Not Hispanic or Latino | 171 | 103.7 | 35.5
| 102-016 | >=65 years/T2DM | 69 | Female | White | Not Hispanic or Latino | 152.7 | 82.1 | 35.2
| 102-018 | >=65 years/T2DM | 70 | Male | White | Not Hispanic or Latino | 177 | 98.6 | 31.5
| 102-020 | >=65 years/T2DM | 77 | Male | White | Not Hispanic or Latino | 163 | 73.3 | 27.6
| 103-002 | >=65 years/Asthma | 78 | Female | White | Not Hispanic or Latino | 159 | 97.1 | 38.4
| 103-004 | >=85 years | 87 | Male | White | Not Hispanic or Latino | 183.5 | 90.8 | 27.0
| 103-006 | >=65 years/Asthma | 67 | Male | White | Not Hispanic or Latino | 193.2 | 88.1 | 23.6
| 103-010 | >=65 years/1+ ER Visits/Hospitalizations for RTI During Prior 12 Months | 80 | Female | White | Not Hispanic or Latino | 164 | 64.6 | 24.0
| 103-020 | >=65 years/Asthma | 75 | Male | White | Not Hispanic or Latino | 177.6 | 84.7 | 26.9
| 104-001 | >=65 years/Chronic Bronchitis or COPD | 68 | Male | White | Not Hispanic or Latino | 171 | 58.1 | 19.9
| 104-003 | >=65 years/T2DM | 70 | Female | White | Not Hispanic or Latino | 154 | 78.5 | 33.1
| 104-004 | >=65 years/Chronic Bronchitis or COPD | 70 | Male | White | Not Hispanic or Latino | 170 | 71.4 | 24.7
| 104-008 | >=65 years/Current Smoker | 72 | Male | White | Not Hispanic or Latino | 179.5 | 60.2 | 18.7
| 104-010 | >=65 years/Asthma | 76 | Female | White | Not Hispanic or Latino | 161.5 | 84.5 | 32.4
| 104-012 | >=65 years/Current Smoker | 73 | Male | White | Not Hispanic or Latino | 163 | 55.2 | 20.8
| 104-017 | >=85 years | 86 | Female | White | Not Hispanic or Latino | 173 | 61.5 | 20.5
| 105-001 | >=65 years/Chronic Bronchitis or COPD | 65 | Female | White | Not Hispanic or Latino | 165 | 96.9 | 35.6
| 105-005 | >=65 years/T2DM | 67 | Male | White | Not Hispanic or Latino | 176 | 104.1 | 33.6

Notes: Full Analysis Set includes randomized, treated subjects with at least part of one dose of study treatment, as-treated.
Body Mass Index (BMI) is derived using the formula BMI = (weight/height^2).

Output: l-demo     Snapshot Date: 22 August 2022
S:\PROD\LISTINGS\PGM\L-DEMO.sas

Listing 16.1
Demographic and Baseline Characteristics
Full Analysis Set

Treatment Arm

Subject Number

Randomization Factor

Age (years)

Gender

Race

Ethnicity

Height
(cm)

Weight
(kg)

BMI
(kg/
m2)

Placebo | 105-006 | >=65 years/T2DM | 69 | Male | White | Not Hispanic or Latino | 182 | 117 | 35.3
| 105-007 | >=65 years/T2DM | 78 | Female | White | Not Hispanic or Latino | 164.5 | 112.2 | 41.5
| 105-009 | >=85 years | 87 | Female | White | Not Hispanic or Latino | 162 | 58 | 22.1
| 105-011 | >=65 years/T2DM | 80 | Male | White | Not Hispanic or Latino | 166.2 | 78.3 | 28.3
| 105-014 | >=85 years | 85 | Female | White | Not Hispanic or Latino | 160.4 | 69.9 | 27.2
| 105-015 | >=65 years/Asthma | 80 | Female | White | Not Hispanic or Latino | 176 | 74 | 23.9
| 105-016 | >=65 years/Chronic Bronchitis or COPD | 69 | Male | White | Not Hispanic or Latino | 177 | 91.2 | 29.1
| 106-001 | >=65 years/Chronic Bronchitis or COPD | 70 | Male | White | Not Hispanic or Latino | 169.3 | 81.8 | 28.5
| 106-006 | >=65 years/Chronic Bronchitis or COPD | 72 | Male | White | Not Hispanic or Latino | 174.7 | 97.4 | 31.9
| 106-009 | >=65 years/T2DM | 70 | Male | White | Not Hispanic or Latino | 175 | 88.7 | 29.0
| 107-006 | >=65 years/Chronic Bronchitis or COPD | 69 | Male | White | Not Hispanic or Latino | 184.3 | 83.2 | 24.5
| 107-007 | >=65 years/Chronic Bronchitis or COPD | 73 | Male | White | Not Hispanic or Latino | 163.4 | 80.6 | 30.2
| 107-010 | >=65 years/T2DM | 76 | Female | Native Hawaiian or Other Pacific Islander | Not Hispanic or Latino | 151 | 59.6 | 26.1
| 107-016 | >=85 years | 93 | Male | White | Not Hispanic or Latino | 161.5 | 73.5 | 28.2
| 107-018 | >=85 years | 90 | Female | White | Not Hispanic or Latino | 154 | 66 | 27.8
| 107-020 | >=65 years/Chronic Bronchitis or COPD | 69 | Male | White | Not Hispanic or Latino | 174.9 | 102.9 | 33.6
| 107-022 | >=85 years | 86 | Female | White | Not Hispanic or Latino | 160.6 | 75.1 | 29.1
| 107-026 | >=85 years | 85 | Female | White | Not Hispanic or Latino | 158.2 | 84 | 33.6
| 108-005 | >=65 years/Current Smoker | 65 | Male | White | Not Hispanic or Latino | 178.5 | 86.4 | 27.1
| 108-006 | >=65 years/T2DM | 74 | Male | White | Not Hispanic or Latino | 173.5 | 114.6 | 38.1
| 108-011 | >=65 years/Current Smoker | 72 | Male | White | Not Hispanic or Latino | 172.5 | 73.5 | 24.7

Notes: Full Analysis Set includes randomized, treated subjects with at least part of one dose of study treatment, as-treated.
Body Mass Index (BMI) is derived using the formula BMI = (weight/height^2).

Output: l-demo     Snapshot Date: 22 August 2022
S:\PROD\LISTINGS\PGM\L-DEMO.sas

Listing 16.1
Demographic and Baseline Characteristics
Full Analysis Set

Treatment Arm

Subject Number

Randomization Factor

Age (years)

Gender

Race

Ethnicity

Height
(cm)

Weight
(kg)

BMI
(kg/
m2)

Placebo | 108-012 | >=65 years/T2DM | 69 | Male | Other: White and Native Hawaiian or Other Pacific Islander | Not Hispanic or Latino | 183.5 | 113.8 | 33.8
| 108-013 | >=65 years/Asthma | 68 | Female | White | Not Hispanic or Latino | 165 | 86.5 | 31.8
| 108-027 | >=65 years/T2DM | 65 | Female | White | Not Hispanic or Latino | 161.9 | 113.9 | 43.5
| 109-002 | >=65 years/T2DM | 69 | Male | White | Not Hispanic or Latino | 168.5 | 79.3 | 27.9
| 109-016 | >=85 years | 86 | Female | White | Not Hispanic or Latino | 145.5 | 49 | 23.1
| 109-018 | >=85 years | 85 | Male | White | Not Hispanic or Latino | 172 | 76.7 | 25.9
| 109-022 | >=65 years/Asthma | 72 | Male | White | Not Hispanic or Latino | 179 | 112.8 | 35.2
| 109-023 | >=65 years/T2DM | 67 | Male | White | Not Hispanic or Latino | 179 | 66.5 | 20.8
| 110-001 | >=65 years/Asthma | 77 | Female | White | Not Hispanic or Latino | 159.8 | 49.8 | 19.5
| 110-004 | >=85 years | 86 | Female | White | Not Hispanic or Latino | 161.4 | 79.4 | 30.5

Notes: Full Analysis Set includes randomized, treated subjects with at least part of one dose of study treatment, as-treated.
Body Mass Index (BMI) is derived using the formula BMI = (weight/height^2).

Output: l-demo     Snapshot Date: 22 August 2022
S:\PROD\LISTINGS\PGM\L-DEMO.sas