Listing 16.2.4       Demographics and Baseline Characteristics (Safety Population)                                                     


  Treatment Group = Clevidipine                                                                                                        
  __________________________________________________________________________________________________________________________________   

                                                                                                                               SBP     
  Patient                                                                                                                    Target    
  ID/                                                                                                                 NYHA    Range    
  Age/     Treatment                               Weight  Height    BMI      BNP       NT-proBNP                      HF    (mmHg)    
  Sex      Start/Stop       Race       Ethnicity    (kg)    (cm)   (kg/m^2)   (pg/mL)   (pg/mL)     Chest X-Ray       Score    U/L     
  __________________________________________________________________________________________________________________________________   

  100001/  14APR10:10:26/   Black or   Not          68.3   170.2     23.6     2080.0                Pleural Effusion  IV     180/140   
  51/      14APR10:15:05    African    Hispanic                                                                                        
  Female                    American   or Latino                                                                                       
                                                                                                    Vascular                           
                                                                                                    Congestion or                      
                                                                                                    Redistribution                     
                                                                                                    Cardiomegaly                       

  101002/  08FEB10:20:42/   Black or   Not          77.3   177.8     24.5     1070.0                Pleural Effusion  IV     140/100   
  57/      08FEB10:22:35    African    Hispanic                                                                                        
  Male                      American   or Latino                                                                                       

  101003/  20FEB10:12:38/   Black or   Not          84.1   172.7     28.2     1280.0   *12000.0     No Evidence of    II     150/110   
  57/      20FEB10:15:15    African    Hispanic                                                     AHF                                
  Male                      American   or Latino                                                                                       
                                                                                                    Cardiomegaly                       

  101006/  03JAN11:11:32/   Black or   Not         100.9   171.5     34.3      384.0                Vascular          II     150/110   
  44/      03JAN11:15:08    African    Hispanic                                                     Congestion or                      
  Female                    American   or Latino                                                    Redistribution                     
                                                                                                    Cardiomegaly                       

  101008/  06FEB12:21:01/   Black or   Not          89.1   165.1     32.7     5000.0   *70000.0     Pleural Effusion  III    150/110   
  61/      06FEB12:22:15    African    Hispanic                                                                                        
  Female                    American   or Latino                                                                                       
                                                                                                    Cardiomegaly                       



______________________________________________________________________________________________________________________________________
_
BMI=Body Mass Index  SBP=Systolic Blood Pressure  U/L=Upper/Lower Limit.                                                               
Prefix '*' for BNP and NT-proBNP indicates that the baseline data are missing and first post treatment data are included.              
Prefix '*' for Chest X-Ray indicates that the baseline X-Ray is missing and X-Ray data within 3 hours post treatment are included.     

Compound: Clevidipine (TMC-CLV-08-01), SAS Program: L_DEMOG.SAS                     /Date: 05JUL2012 14:32               (Page 1 of 
22)

Listing 16.2.4       Demographics and Baseline Characteristics (Safety Population)                                                     


  Treatment Group = Clevidipine                                                                                                        
  __________________________________________________________________________________________________________________________________   

                                                                                                                               SBP     
  Patient                                                                                                                    Target    
  ID/                                                                                                                 NYHA    Range    
  Age/     Treatment                               Weight  Height    BMI      BNP       NT-proBNP                      HF    (mmHg)    
  Sex      Start/Stop       Race       Ethnicity    (kg)    (cm)   (kg/m^2)   (pg/mL)   (pg/mL)     Chest X-Ray       Score    U/L     
  __________________________________________________________________________________________________________________________________   

  102001/  01SEP09:13:39/   Black or   Not          77.3   172.7     25.9               25579.0     Acute Pulmonary   III    160/120   
  47/      01SEP09:15:47    African    Hispanic                                                     Edema,                             
  Male                      American   or Latino                                                    Including                          
                                                                                                    Interstitial or                    
                                                                                                    Alveolar Edema                     

  102004/  01OCT09:13:08/   White      Not          87.7   180.3     27.0                7633.0     Pleural Effusion  III    160/120   
  77/      01OCT09:16:48               Hispanic                                                                                        
  Female                               or Latino                                                                                       
                                                                                                    Acute Pulmonary                    
                                                                                                    Edema,                             
                                                                                                    Including                          
                                                                                                    Interstitial or                    
                                                                                                    Alveolar Edema                     

  102008/  10DEC09:15:27/   Black or   Not          73.0   158.0     29.2     3366.0    31793.0     Pleural Effusion  IV     160/120   
  66/      10DEC09:17:30    African    Hispanic                                                                                        
  Female                    American   or Latino                                                                                       
                                                                                                    Acute Pulmonary                    
                                                                                                    Edema,                             
                                                                                                    Including                          
                                                                                                    Interstitial or                    
                                                                                                    Alveolar Edema                     
                                                                                                    Cardiomegaly                       

  102010/  26MAR10:11:27/   Black or   Not          69.0   157.0     28.0                           Pleural Effusion  IV     180/140   
  60/      26MAR10:13:08    African    Hispanic                                                                                        
  Male                      American   or Latino                                                                                       



______________________________________________________________________________________________________________________________________
BMI=Body Mass Index  SBP=Systolic Blood Pressure  U/L=Upper/Lower Limit.                                                               
Prefix '*' for BNP and NT-proBNP indicates that the baseline data are missing and first post treatment data are included.              
Prefix '*' for Chest X-Ray indicates that the baseline X-Ray is missing and X-Ray data within 3 hours post treatment are included.     

Compound: Clevidipine (TMC-CLV-08-01), SAS Program: L_DEMOG.SAS                     /Date: 05JUL2012 14:32               (Page 2 of 
22)